Regulation of Sterol Homeostasis - Tabular View

Tracking Information

First Received Date ^ICMJE

July 3, 2001

Last Updated Date

January 20, 2009

Start Date ^ICMJE

April 1996

Primary Completion Date

Current Primary Outcome Measures ^ICMJE

Original Primary Outcome Measures ^ICMJE

Change History

Complete list of historical versions of study NCT00018720 on ClinicalTrials.gov Archive Site

Current Secondary Outcome Measures ^ICMJE

Original Secondary Outcome Measures ^ICMJE

Descriptive Information

Brief Title ^ICMJE

Regulation of Sterol Homeostasis

Official Title ^ICMJE

Regulation of Sterol Homeostasis

Brief Summary

The purpose of this study is to determine how people with high triglycerides metabolize and absorb bile acids, compounds made in the body from cholesterol.

This project has two objectives: A) To define the mechanism of impaired bile acid absorption in hypertriglyceridemia (specifically we will determine if the active or passive component of absorption is abnormal) and B) to determine the contribution of an alternative pathway of bile acid synthesis which begins with 27-hydroxylation of cholesterol. Because 27-hydroxylase is present in endothelial cells as well as liver, this pathway may play a role in removal of cholesterol from incipient atherosclerotic plaque.

Detailed Description

Study Phase

Study Type ^ICMJE

Observational

Study Design ^ICMJE

Prospective

Condition ^ICMJE

Hypertriglyceridemia

Intervention ^ICMJE

Study Arms / Comparison Groups

Publications *

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status ^ICMJE

Completed

Enrollment ^ICMJE

Completion Date

December 2000

Primary Completion Date

Eligibility Criteria ^ICMJE

Hypertriglyceridemia and normal controls with normal lipids

Gender

Both

Ages

18 Years to 75 Years

Accepts Healthy Volunteers

Yes

Contacts ^ICMJE

Contact information is only displayed when the study is recruiting subjects

Location Countries ^ICMJE

United States

Administrative Information

NCT ID ^ICMJE

NCT00018720

Responsible Party

Study ID Numbers ^ICMJE

GAST-026-95F

Study Sponsor ^ICMJE

Department of Veterans Affairs

Collaborators ^ICMJE

Investigators ^ICMJE

Investigator:	Norman Javitt, M.D.
Investigator:	Alan Hofmann, M.D.
Investigator:	Loren Zech, M.D.

Information Provided By

Department of Veterans Affairs

Verification Date

December 2004

^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP