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| Sponsored by: |
Department of Veterans Affairs |
| Information provided by: | Department of Veterans Affairs |
| ClinicalTrials.gov Identifier: | NCT00018720 |
Purpose
The purpose of this study is to determine how people with high triglycerides metabolize and absorb bile acids, compounds made in the body from cholesterol.
This project has two objectives: A) To define the mechanism of impaired bile acid absorption in hypertriglyceridemia (specifically we will determine if the active or passive component of absorption is abnormal) and B) to determine the contribution of an alternative pathway of bile acid synthesis which begins with 27-hydroxylation of cholesterol. Because 27-hydroxylase is present in endothelial cells as well as liver, this pathway may play a role in removal of cholesterol from incipient atherosclerotic plaque.
| Condition |
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Hypertriglyceridemia |
| MedlinePlus related topics: | Triglycerides |
| Study Type: | Observational |
| Study Design: | Natural History, Cross-Sectional, Defined Population, Prospective Study |
| Official Title: | Regulation of Sterol Homeostasis |
Eligibility
| Ages Eligible for Study: | 18 Years to 75 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Hypertriglyceridemia and normal controls with normal lipids
Contacts and Locations| United States, Minnesota | |||||
| VA Medical Center | |||||
| Minneapolis, Minnesota, United States, 55417 | |||||
| Investigator: | Norman Javitt, M.D. | |
| Investigator: | Alan Hofmann, M.D. | |
| Investigator: | Loren Zech, M.D. |
More Information
| Study ID Numbers: | GAST-026-95F |
| First Received: | July 3, 2001 |
| Last Updated: | June 23, 2005 |
| ClinicalTrials.gov Identifier: | NCT00018720 |
| Health Authority: | United States: Federal Government |
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