Genotype Influence on Recovery After Traumatic Brain Injury
Genetic differences in response to brain injury may reasonably be expected to play a role in the initial consequences of traumatic brain injury and in the rate of recovery from such injury.
|Official Title:||The Influence of APOE Genotype on Recovery After Traumatic Brain Injury|
|Study Start Date:||October 1998|
|Estimated Study Completion Date:||October 2001|
Polymorphisms in the Apolipoprotein E gene encode functional variants which differentially determine the rate at which neuronal repair can occur, and are associated with differences in expression of neurodegenerative processes, including traumatic brain injury. It is proposed that the accuracy of prediction of outcome after head injury will be significantly increased by inclusion of APOE genotype alone, or in combination with other variables such as severity of head injury, cognitive, electroencephalographic or neuroradiologic measures, or treatment strategies.
|United States, Florida|
|James A. Haley Veterans' Hospital|
|Tampa, Florida, United States, 33612|
|Investigator:||Fiona Crawford, Ph.D.|
|Investigator:||Rodney Vanderploeg, Ph.D.|
|Investigator:||Robert Thatcher, Ph.D.|
|Investigator:||Andres Salazar, M.D.|