Effects of Exercise on Patients With Hemiparetic Stroke
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Purpose
This randomized trial investigates the hypothesis that regular aerobic exercise training using a task specific gait training modality will improve cardiovascular fitness, functional mobility, and reduce risk factors for recurrent cardiovascular events in chronic hemiparetic stroke patients, when compared to matched controls performing just stretching.
| Condition | Intervention |
|---|---|
|
Stroke Hemiplegia Cardiovascular Disease |
Procedure: Treadmill Exercise |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Primary Purpose: Treatment |
| Official Title: | Effects of Exercise on Patients With Hemiparetic Stroke |
| Study Start Date: | July 1997 |
| Estimated Study Completion Date: | June 2001 |
The aims are to determine whether 6 months progressive graded treadmill training: 1) improves cardiovascular fitness levels and reduces the excessive energy demands of hemiparetic gait, as defined by oxygen consumption levels based on open circuit spirometry during peak and submaximal exercise ambulation tasks; 2) increases free living physical activity measured by portable kinematic recording devices and quantitative in vivo determination of energy expenditure using stable isotopes; and, 3) improves the cardiovascular-metabolic risk factor profile including measures of key endogenous fibrinolysis regulatory enzymes [plasma tissue plasminogen activator (t-PA) and its main circulating inhibitor (PAI-1)], fasting lipoprotein lipid profiles, blood pressure, and oral glucose tolerance and insulin responses. Measurements of body composition at baseline and after training will further determine the effects of aerobic exercise training on muscle mass and central obesity.
Eligibility| Ages Eligible for Study: | 40 Years to 80 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Males or Females Ages 40 yrs to 80 yrs who are chronic hemiparetic stroke patients.
Contacts and Locations More Information
No publications provided
| ClinicalTrials.gov Identifier: | NCT00018421 History of Changes |
| Other Study ID Numbers: | CADE-RA |
| Study First Received: | July 3, 2001 |
| Last Updated: | January 20, 2009 |
| Health Authority: | United States: Federal Government |
Keywords provided by Department of Veterans Affairs:
|
Cerebrovascular Disorders Exercise Rehabilitation |
Additional relevant MeSH terms:
|
Cardiovascular Diseases Hemiplegia Stroke Cerebral Infarction Paralysis Neurologic Manifestations Nervous System Diseases |
Signs and Symptoms Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Vascular Diseases Brain Infarction Brain Ischemia |
ClinicalTrials.gov processed this record on May 16, 2013