Dichloroacetate Kinetics, Metabolism and Toxicology

This study has been completed.
Sponsor:
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier:
NCT00015015
First received: April 17, 2001
Last updated: September 1, 2006
Last verified: September 2006
  Purpose

Dichloroacetate (DCA) is a product of water chlorination and a metabolite of certain industrial solvents, thus making it a chemical of environmental concern. However, DCA is also used as an investigational drug for treating various diseases of adults and children, at doses far greater than those to which humans are normally exposed in the environment. Our research involves how DCA is metabolized by healthy adults and by children with a fatal genetic disease, congenital lactic acidosis (CLA) who are treated with DCA.


Condition Intervention
Lactic Acidosis
Drug: Dichloroacetate

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment: 100
Study Start Date: December 1994
Estimated Study Completion Date: October 2002
  Eligibility

Ages Eligible for Study:   3 Months to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Children with congenital lactic acidosis Healthy adult volunteers

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00015015

Locations
United States, Florida
Univ. of Florida
Gainesville, Florida, United States, 32610
Sponsors and Collaborators
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00015015     History of Changes
Other Study ID Numbers: 7355-CP-001
Study First Received: April 17, 2001
Last Updated: September 1, 2006
Health Authority: United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
Dichloroacetate
Chlorinated hydrocarbons
Genetic disease
Toxicology
Biotransformation

Additional relevant MeSH terms:
Acidosis
Acidosis, Lactic
Acid-Base Imbalance
Metabolic Diseases

ClinicalTrials.gov processed this record on August 28, 2014