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Attention Deficit Disorder and Exposure to Lead

This study has been completed.

Sponsored by: National Institute of Environmental Health Sciences (NIEHS)
Information provided by: National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier: NCT00014898
  Purpose

We are examining the past exposure to lead in 250 well characterized children with ADHD, and a suitable group of controls. Our measure of past exposure is bone lead levels obtained by XRay fluorescence spectroscopy, a relatively new way of estimating bone lead concentrations, and by inference, body lead burdens. By comparing the lead concentrations in these two groups, controlling for other factors which could confound, we will estimate odds ratios for ADHD given elevated bone lead, and estimate the contribution of lead to this disease of childhood.


Condition
Attention Deficit Disorder

U.S. FDA Resources

Study Type:   Observational
Study Design:   Case Control, Retrospective Study

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment:   500
Study Start Date:   June 1999
Estimated Study Completion Date:   May 2002

  Eligibility
Ages Eligible for Study:   10 Years to 18 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Criteria

Case subjects are drawn from adolescents aged 10 to 18 previously seen at Western Psychiatric Institute and Clinic for evaluation, and meet the DSM-IIIR criteria for diagnosis of ADHD based on a structured parent interview and standardized parent and teacher rating scales. Cases were also systematically observed and evaluated in the summer treatment program between 1987 and 1996 at WPIC. Controls are demographically matched non-ADHD adolescents, recruited from surrounding communities and pediatric practices.

  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00014898

Locations
United States, Pennsylvania
University of Pittsburgh    
      Pittsburgh, Pennsylvania, United States, 15213

Sponsors and Collaborators
  More Information


Study ID Numbers:   5015-CP-001
First Received:   April 12, 2001
Last Updated:   June 23, 2005
ClinicalTrials.gov Identifier:   NCT00014898
Health Authority:   United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
Lead exposure  
Bone lead  
Attention deficit  

Study placed in the following topic categories:
Attention Deficit Disorder with Hyperactivity
Mental Disorders
Mental Disorders Diagnosed in Childhood
Attention Deficit and Disruptive Behavior Disorders
Hyperkinesis

Additional relevant MeSH terms:
Pathologic Processes
Disease

ClinicalTrials.gov processed this record on November 20, 2008




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