Cardiovascular Vulnerability to Particulate Exposure - Full Text View

Purpose

This project is part of a program project directed toward assessing cardiac effects of particulate and other ambient air pollutants. In this project active elderly adults living in the communities of Boston and Steubenville have attended 12 weekly sessions including approximately 40 minutes of Holter monitoring, blood pressure, and oximetry evaluation before, during, and after outdoor exercise. To investigate the relation of air pollution to cardiac and pulmonary rehabilitation, a second portion of this study involves abstraction of blood pressure and symptom data and downloading of available repeated measures telemetry data in two populations. These populations include: 1) 200 outpatients attending 8 to 36 repeated weekly exercise training sessions in a major hospital cardiac rehabilitation unit.

Condition

Heart Disease
Lung Disease

MedlinePlus related topics:

Heart Diseases

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History, Longitudinal, Defined Population, Prospective Study

Official Title:	Active Elderly Study

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment:	200
Study Start Date:	September 1998
Estimated Study Completion Date:	September 2004

Detailed Description:

Approximately 60 subjects have participated fully in Boston and Steubenville in the repeated 40 minute measurement of continuous EKG (Holter), blood pressure, and oximetry. In Steubenville we have also measured exhaled nitrogen oxide, an index of pulmonary inflammation. The exposure monitoring has included outdoor particle mass of PM2.5, outdoor gaseous pollutants, and indoor home and personal monitoring to evaluate the indoor contribution of pollution to health effects.

Eligibility

Ages Eligible for Study:	50 Years to 90 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Participants are 50 to 90 years of age, but almost all are 60 and older. They have been enrolled as volunteers from communities in Mission Park, Boston, and Steubenville. Inclusion criteria includes the ability to walk on level ground. Exclusion criteria includes unstable anginal, and baseline EKG patterns such as left bundle branch block that would make difficult the detection of repolarization abnormalities. Participants live at or near the study center which was located in an office or apartment in the apartment building of the majority of the participants.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00013949

Locations


United States, Massachusetts
	Brigham and Women's Hospital
	Boston, Massachusetts, United States, 02115

Sponsors and Collaborators

National Institute of Environmental Health Sciences (NIEHS)

Investigators


Study Director:	Diane Gold, MD	Harvard School of Public Health

Principal Investigator:	Frank E Speizer, MD	Harvard School of Public Health

More Information

Study ID Numbers:	9825-CP-003
First Received:	April 3, 2001
Last Updated:	September 1, 2006
ClinicalTrials.gov Identifier:	NCT00013949
Health Authority:	United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):

Holter monitoring

ECG

Cardiac

particulate exposure

Study placed in the following topic categories:

Heart Diseases

Respiratory Tract Diseases

Lung Diseases

Additional relevant MeSH terms:

Cardiovascular Diseases

ClinicalTrials.gov processed this record on September 05, 2008

Sponsored by:	National Institute of Environmental Health Sciences (NIEHS)
Information provided by:	National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier:	NCT00013949