ClinicalTrials.gov
 Home    Search    Study Topics    Glossary  
 

  Full Text View  
  Tabular View  
  Contacts and Locations  
  No Study Results Posted  
  Related Studies  
Protection Against Benzene Toxicity

This study has been completed.

Sponsored by: National Institute of Environmental Health Sciences (NIEHS)
Information provided by: National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier: NCT00011453
  Purpose

We are investigating the role of an enzyme (NQO1) in protection against the bone marrow toxicity of the occupational and environmental toxicant benzene. All of the proposed studies involve use of human bone marrow cells in-vitro to define mechanisms of NQO1-mediated protection. Cells are obtained from healthy volunteers and protocols have undergone IRB review and approval.


Condition
Leukemia
Aplastic Anemia

MedlinePlus related topics:   Anemia    Leukemia, Adult Acute    Leukemia, Adult Chronic   

U.S. FDA Resources

Study Type:   Observational
Study Design:   Screening, Convenience Sample, Prospective Study
Official Title:   NQO1 in Protection Against Benzene Toxicity

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Study Start Date:   July 1998
Estimated Study Completion Date:   June 2001

  Eligibility
Ages Eligible for Study:   21 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Criteria

Healthy adult volunteers with blood counts in normal ranges and without evidence of hepatitis or HIV infection.

  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00011453

Locations
United States, Colorado
University of Colorado Health Sciences Center    
      Denver, Colorado, United States, 80262

Sponsors and Collaborators
  More Information


Study ID Numbers:   9554-CP-001
First Received:   February 21, 2001
Last Updated:   June 23, 2005
ClinicalTrials.gov Identifier:   NCT00011453
Health Authority:   United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
NQO1  
DT-diaphorase  
Benzene  
Leukemia  
Aplastic anemia  

Study placed in the following topic categories:
Leukemia
Hematologic Diseases
Anemia, Aplastic
Anemia
Aplastic anemia
Bone Marrow Diseases

Additional relevant MeSH terms:
Neoplasms
Neoplasms by Histologic Type

ClinicalTrials.gov processed this record on October 10, 2008




Links to all studies - primarily for crawlers