Pollutant Altered Allergic Responses
This study is designed to investigate whether exposure to particulate air pollution increases the allergic response to allergens. Research studies suggest that symptoms in individuals with allergies may be aggravated by exposure to particulate air pollution. We sought to experimental determine this by exposing human volunteers to combustion particles, a component of air pollution, and then challenge them with an allergen such as ragweed or oak tree pollen. Using biological tests we can measure whether the allergen response is magnified by prior particulate exposure.
|Study Design:||Allocation: Random Sample
Observational Model: Natural History
Time Perspective: Longitudinal
|Official Title:||Markers of Pollutant Altered Allergic Responses|
|Study Start Date:||December 1998|
|Estimated Study Completion Date:||August 2002|
To study whether particulates enhance the allergic response, we chose the upper airway as a model of allergic inflammation and nasal lavage as a non-invasive method for obtaining samples. The nasal cavity is both an excellent model of allergic inflammation and provides an easily accessible site for study. We measured inflammatory cells and cytokines in the nasal lavage fluid. Our specific hypothesis was that particulate exposure prior to allergen challenge would enhance inflammatory cell recruitment and expression of inflammatory cytokines.
|United States, Massachusetts|
|Harvard School of Public Health|
|Boston, Massachusetts, United States, 02115|