Pollutant Altered Allergic Responses

This study has been completed.
Sponsor:
Information provided by:
National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier:
NCT00011440
First received: February 20, 2001
Last updated: March 22, 2006
Last verified: March 2006
  Purpose

This study is designed to investigate whether exposure to particulate air pollution increases the allergic response to allergens. Research studies suggest that symptoms in individuals with allergies may be aggravated by exposure to particulate air pollution. We sought to experimental determine this by exposing human volunteers to combustion particles, a component of air pollution, and then challenge them with an allergen such as ragweed or oak tree pollen. Using biological tests we can measure whether the allergen response is magnified by prior particulate exposure.


Condition
Allergic Rhinitis
Allergy

Study Type: Observational
Study Design: Allocation: Random Sample
Observational Model: Natural History
Time Perspective: Longitudinal
Official Title: Markers of Pollutant Altered Allergic Responses

Resource links provided by NLM:


Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment: 20
Study Start Date: December 1998
Estimated Study Completion Date: August 2002
Detailed Description:

To study whether particulates enhance the allergic response, we chose the upper airway as a model of allergic inflammation and nasal lavage as a non-invasive method for obtaining samples. The nasal cavity is both an excellent model of allergic inflammation and provides an easily accessible site for study. We measured inflammatory cells and cytokines in the nasal lavage fluid. Our specific hypothesis was that particulate exposure prior to allergen challenge would enhance inflammatory cell recruitment and expression of inflammatory cytokines.

  Eligibility

Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Adult without a history of asthma or respiratory disease.

  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00011440

Locations
United States, Massachusetts
Harvard School of Public Health
Boston, Massachusetts, United States, 02115
Sponsors and Collaborators
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00011440     History of Changes
Other Study ID Numbers: 8077-CP-001
Study First Received: February 20, 2001
Last Updated: March 22, 2006
Health Authority: United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
Allergy
Air pollution
Lung function
Inflammation

Additional relevant MeSH terms:
Hypersensitivity
Rhinitis
Rhinitis, Allergic, Perennial
Immune System Diseases
Nose Diseases
Respiratory Tract Diseases
Respiratory Tract Infections
Otorhinolaryngologic Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate

ClinicalTrials.gov processed this record on August 28, 2014