Role of Altered CD40-Ligand Gene Transcription in Systemic Lupus Erythematosus
The recruitment status of this study is unknown because the information has not been verified recently.
Verified December 2003 by National Center for Research Resources (NCRR).
Recruitment status was Recruiting
Recruitment status was Recruiting
Sponsor:
Collaborator:
Arthritis Foundation
Information provided by:
National Center for Research Resources (NCRR)
ClinicalTrials.gov Identifier:
NCT00008749
First received: January 16, 2001
Last updated: June 23, 2005
Last verified: December 2003
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Purpose
Systemic lupus erythematosus is an often devastating autoimmune disease which affects 1 in 2,000 women in the United States. Recently, several research laboratories have reported that a protein, named CD40-ligand (CD154), is overexpressed by a subset of white blood cells, called lymphocytes, in patients with lupus. Expression of CD154 appears critical to the generation of antibodies that cause disease in lupus. Blocking CD154 interactions in the immune system has been shown to decrease disease activity in animal models of lupus. We propose to study the regulation of CD154 in patients with lupus in hopes of inhibiting its abnormal and deleterious expression.
| Condition |
|---|
|
Lupus Erythematosus, Systemic |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Observational Model: Natural History |
| Official Title: | Role of Altered CD40-Ligand Gene Transcription in Systemic Lupus Erythematosus |
Resource links provided by NLM:
Further study details as provided by National Center for Research Resources (NCRR):
Eligibility| Ages Eligible for Study: | 13 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Criteria
Inclusion:
A diagnosis of systemic lupus erythematosus
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00008749
Contacts
| Contact: Randy Q Cron, MD, Ph.D. | 215-590-1844 |
Locations
| United States, Pennsylvania | |
| Children's Hospital of Philadelphia | Recruiting |
| Philadelphia, Pennsylvania, United States, 19104-4318 | |
| Contact: Randy Q Cron, M.D., Ph.D. 215-590-1844 | |
Sponsors and Collaborators
Arthritis Foundation
More Information
No publications provided
| ClinicalTrials.gov Identifier: | NCT00008749 History of Changes |
| Other Study ID Numbers: | NCRR-M01RR00240-1736 |
| Study First Received: | January 16, 2001 |
| Last Updated: | June 23, 2005 |
| Health Authority: | United States: Federal Government |
Additional relevant MeSH terms:
|
Lupus Erythematosus, Systemic Connective Tissue Diseases Autoimmune Diseases Immune System Diseases |
ClinicalTrials.gov processed this record on May 21, 2013