|
|
![]() |
![]() |
![]() |
![]() |
|
![]() |
|
![]() |
|
![]() |
|
![]() |
![]() |
![]() |
|
![]() |
|||||||||||||||||||||||||||||||||||||||||||||
| Sponsors and Collaborators: |
National Center for Research Resources (NCRR) Mount Sinai School of Medicine |
| Information provided by: | National Center for Research Resources (NCRR) |
| ClinicalTrials.gov Identifier: | NCT00007046 |
Purpose
OBJECTIVES: I. Identify and characterize the gene causing diaphyseal medullary stenosis with malignant fibrous histiocytoma of the bone.
II. Determine the clinical manifestations of this disease in these patients.
| Condition |
|
Stenosis Histiocytoma |
| MedlinePlus related topics: | Cancer |
| Study Type: | Observational |
| Study Design: | Screening |
| Study Start Date: | August 2000 |
PROTOCOL OUTLINE: Blood samples are obtained from affected individuals and their family members after genetic counseling. Genetic linkage analysis is performed on these blood samples. Unaffected individuals undergo x-rays and technetium bone scans to detect the presence of bone disease. Affected individuals undergo bone densitometry, MRI studies, thallium scans, ophthalmologic examination, electrocardiogram, echocardiogram, and skin biopsies.
Affected family members identified after radiologic studies receive additional genetic counseling.
Eligibility
| Ages Eligible for Study: | up to 90 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
PROTOCOL ENTRY CRITERIA:
--Disease Characteristics--
Diagnosis of diaphyseal medullary stenosis with malignant fibrous histiocytoma of the bone
OR
Family member, including spouses, of an affected individual
--Patient Characteristics--
Renal: Not specified
Contacts and Locations| United States, New York | |||||
| Mount Sinai School of Medicine | |||||
| New York, New York, United States, 10029 | |||||
| National Center for Research Resources (NCRR) |
| Mount Sinai School of Medicine |
| Study Chair: | J.A. Martignetti | Mount Sinai School of Medicine |
More Information
| Study ID Numbers: | 199/15489, MTS-97-304-0001-HG, MTS-GCO-97-304HG |
| First Received: | December 6, 2000 |
| Last Updated: | June 23, 2005 |
| ClinicalTrials.gov Identifier: | NCT00007046 |
| Health Authority: | United States: Federal Government |
|
|
|
|
|