RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining these two treatments may kill more tumor cells.

PURPOSE: Phase II trial to study the effectiveness of combining vaccine therapy with radiation therapy in treating patients who have stage II or stage IIIA non-small cell lung cancer that has been completely removed in surgery.

OBJECTIVES:

• Determine the humoral and T-cell response to adjuvant monoclonal antibody 11D10 anti-idiotype vaccine and monoclonal antibody 3H1 anti-idiotype vaccine with radiotherapy in patients with completely resected stage II or IIIA non-small cell lung cancer.
• Determine the qualitative and quantitative toxicity and reversibility of toxicity of this regimen in these patients.
• Determine the progression-free and overall survival of patients treated with this regimen.

OUTLINE: This is a multicenter study.

Patients receive monoclonal antibody 11D10 anti-idiotype vaccine and monoclonal antibody 3H1 anti-idiotype vaccine intracutaneously in separate sites once weekly for 3 weeks beginning 2-7 weeks (no later than 49 days) after surgery and then subcutaneously once monthly for 2 years regardless of disease progression. Beginning no more than 1 week after the third postoperative vaccination, all patients undergo radiotherapy 5 days a week for 5-6 weeks. Patients with extracapsular nodal metastases or T3 lesions also undergo 6 additional radiotherapy boosts.

Patients are followed at 4-6 weeks, every 3 months for 1 year, every 4 months for 1 year, every 6 months for 3 years, and then annually thereafter.

PROJECTED ACCRUAL: A total of 54 patients will be accrued for this study.

• Biological: monoclonal antibody 11D10 anti-idiotype vaccine
• Biological: monoclonal antibody 3H1 anti-idiotype vaccine
• Radiation: radiation therapy

DISEASE CHARACTERISTICS:

• Histologically confirmed stage II or IIIA non-small cell lung cancer

  • T1-3, N1-2, M0
  • No stage IIIB (e.g., contralateral N3), stage IV (M1), or T3, N0, M0 disease
  • N1 disease eligible only if hilar lymph node involvement present
  • No bronchoalveolar carcinoma with lobar or multilobar involvement
  • No small cell lung carcinoma, including mixed histology

• No more than 7 weeks since prior surgery (lobectomy, sleeve resection, bilobectomy, or pneumonectomy)

  • Negative surgical margins
  • No incompletely resected gross disease OR
  • No microscopically positive bronchial or vascular margins
• No known CNS metastasis

PATIENT CHARACTERISTICS:

Age:

• 18 and over

Performance status:

• Zubrod 0-1

Life expectancy:

• Not specified

Hematopoietic:

• Absolute neutrophil count at least 2,000/mm^3
• Platelet count at least 100,000/mm^3

Hepatic:

• Not specified

Renal:

• Creatinine no greater than 1.5 mg/dL OR
• Creatinine clearance greater than 60 mL/min

Cardiovascular:

• No superior vena cava syndrome

Pulmonary:

• FEV_1 at least 1.0 L

Gastrointestinal:

• No prior celiac disease, familial polyposis, Turcot's syndrome, Gardner's syndrome, Peutz-Jegher's syndrome, or hereditary non-polyposis colon cancer
• No prior colitis, inflammatory bowel disease, or pancreatitis within the past 10 years

Other:

• Not pregnant
• Negative pregnancy test
• Fertile patients must use effective contraception
• No known sensitivity to rodent proteins
• No prior hypersensitivity or contraindication to study treatments (e.g., monoclonal antibody 11D10 anti-idiotype vaccine, monoclonal antibody 3H1 anti-idiotype vaccine, aluminum hydroxide, or murine proteins) or any excipients
• No prior clinically significant hypersensitivity reactions (e.g., angioedema, anaphylaxis, or serious dermatological manifestations) or asthmatic attacks requiring hospitalization
• No prior immune or immunodeficiency disorders (e.g., HIV, sarcoidosis, tuberculosis, rheumatoid arthritis, or autoimmune disorders)
• No prior seizure disorder requiring continuous medication
• No active infection
• No other prior or concurrent malignancy within the past 3 years except surgically treated carcinoma in situ of the cervix or squamous cell or basal cell skin cancer
• No medical contraindication to surgery, radiotherapy, or immunotherapy
• No prior drug or alcohol abuse (excluding nicotine) within the past 12 months
• No prior psychiatric or addictive disorder that would preclude study compliance

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• No prior murine antibodies (e.g., OncoScint scan)
• No prior monoclonal antibody 11D10 anti-idiotype vaccine, monoclonal antibody 3H1 anti-idiotype vaccine, or other investigational carcinoembryonic antigen-derived therapy
• At least 3 years since other prior immunotherapy
• At least 30 days since prior immunization (e.g., influenza)
• No immunomodulatory therapy (e.g., gold, auranofin, hydroxychloroquine, sulfasalazine, penicillamine, levamisole, dapsone, azathioprine, intravenous immunoglobulin, leukotriene antagonists, cromoglycate, ketotifen, nedocromil, psoralin-ultraviolet-light, or plasmapheresis) within 30 prior to the first dose of study drug or 5 half-lives of the action of the agent, whichever is longer

Chemotherapy:

• At least 3 years since prior chemotherapy except topical therapy
• No concurrent methotrexate or cyclophosphamide

Endocrine therapy:

• At least 45 days since prior corticosteroids
• No concurrent systemic corticosteroids

Radiotherapy:

• No prior thoracic radiotherapy

Surgery:

• See Disease Characteristics

Other:

• At least 45 days since prior immunosuppressants
• No investigational agents within 30 prior to the first dose of study drug or 5 half-lives of the action of the agent, whichever is longer
• No concurrent amifostine
• No concurrent cyclosporine
• No other concurrent immunosuppressants
• No concurrent chronic systemic antihistamines