Gemcitabine in Treating Patients With Persistent or Recurrent Cancer of the Cervix

DISEASE CHARACTERISTICS:

• Diagnosis of persistent or recurrent nonsquamous cell carcinoma of the cervix that has failed local therapeutic measures and is considered incurable

  • Eligible subtypes:

    • Adenocarcinoma
    • Adenosquamous carcinoma
    • Undifferentiated carcinoma
  • Must have documented disease progression
  • Histologic confirmation of original primary tumor required
• Bidimensionally measurable disease
• Ineligible for higher priority GOG protocol

PATIENT CHARACTERISTICS:

Age:

• 18 and over

Performance status:

• GOG 0-2

Life expectancy:

• Not specified

Hematopoietic:

• Platelet count at least 100,000/mm^3
• Granulocyte count at least 1,500/mm^3

Hepatic:

• Bilirubin no greater than 1.5 times normal
• SGOT and alkaline phosphatase no greater than 3 times normal

Renal:

• Creatinine no greater than 1.5 mg/dL

Other:

• No significant infection
• Not pregnant
• Fertile patients must use effective contraception
• No other invasive malignancy within the past 5 years except nonmelanomatous skin cancer

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• No concurrent filgrastim (G-CSF)

Chemotherapy:

• No prior gemcitabine
• At least 3 weeks since other prior chemotherapy for cervical cancer and recovered
• No more than 1 prior chemotherapy regimen (single or combination cytotoxic therapy)

Endocrine therapy:

• Not specified

Radiotherapy:

• At least 3 weeks since prior radiotherapy for cervical cancer and recovered

Surgery:

• At least 3 weeks since prior surgery for cervical cancer and recovered

Other:

• No prior cancer treatment that would preclude study