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Trial record 10 of 28 for:    Open Studies | islet cell transplantation
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Does Islet Transplantation Eliminate Hypoglycemia?

The recruitment status of this study is unknown because the information has not been verified recently.
Verified November 2001 by National Center for Research Resources (NCRR).
Recruitment status was  Not yet recruiting
Sponsor:
Information provided by:
National Center for Research Resources (NCRR)
ClinicalTrials.gov Identifier:
NCT00006068
First received: July 18, 2000
Last updated: June 23, 2005
Last verified: November 2001
History of Changes
  Purpose

Low blood sugar (hypoglycemia) is a recurrent problem for many people with diabetes. Successful transplantation of clusters (islets) of normal cells, that include those which produce the sugar-lowering hormone insulin, from the pancreas of a person who did not have diabetes into a person with diabetes should eliminate high blood sugar levels. We wish to determine if it will also eliminate low blood sugar. To do so we will give insulin to lower the blood sugar, measure the levels of the hormones that normally raise blood sugar levels (e.g., glucagon and epinephrine) and then stop the insulin and see if blood sugar levels return to normal. Because we anticipate that the transplanted islets will produce insulin, but not glucagon, this study may also tell us if regulated insulin production alone can prevent hypoglycemia in humans.


Condition Intervention
Diabetes Mellitus
 Procedure: Pancreatic Islet Transplantation

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Masking: Single Blind
Primary Purpose: Treatment

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by National Center for Research Resources (NCRR):

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Clinically stable, insulin dependent islet transplant recipients and matched nondiabetic healthy controls
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00006068

Contacts
Contact: Philip E. Cryer, M.D. 1-314-362-7635 pcryer@imgate.wustl.edu

Sponsors and Collaborators
National Center for Research Resources (NCRR)
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00006068     History of Changes
Other Study ID Numbers: NCRR-M01RR00036-0746, M01RR00036
Study First Received: July 18, 2000
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Diabetes Mellitus
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases

ClinicalTrials.gov processed this record on May 19, 2013