Genetics of Recurrent Early-Onset Depression

This study has been completed.
Sponsor:
Information provided by:
National Institute of Mental Health (NIMH)
ClinicalTrials.gov Identifier:
NCT00005914
First received: June 15, 2000
Last updated: December 16, 2009
Last verified: February 2009
  Purpose

This nationwide study will create a DNA collection to permit qualified scientists to search for depression-related genes.

More than 750 families with at least two siblings who have experienced major depression are needed for the study. Participants will be interviewed about psychiatric and family history, and will be asked to provide a small blood specimen. The identification of predisposing genes can lead to greater understanding of the brain mechanisms involved in severe depression which can in turn lead to the discovery of new treatments.

A Certificate of Confidentiality from the federal government ensures that all information will be strictly confidential. Blood specimens are identified only by code number (not by name).

Reimbursement is provided.


Condition
Depression

Study Type: Observational
Study Design: Time Perspective: Retrospective

Resource links provided by NLM:


Further study details as provided by National Institute of Mental Health (NIMH):

Study Start Date: October 1999
Estimated Study Completion Date: September 2003
Detailed Description:

Studies of patterns of major depression in families suggest that 50 to 70% of the predisposition to major depression is caused by genes. People with recurrent depression and earlier ages of onset have more relatives with depression. There are probably at least several interacting genes, rather than a single gene as in some disorders. The identification of predisposing genes is likely to lead to greater understanding of the brain mechanisms involved in severe depression. This could lead to the discovery of new treatments.

This study will create a DNA collection to permit qualified scientists to search for depression-related genes. More than 750 families with at least two siblings who have experienced major depression are needed for the study.

Participants in this study will be interviewed about psychiatric and family history, and will be asked for a small blood specimen. Interviews can be conducted in person or by telephone. For telephone interviews, blood sample collection will be arranged at a location and time convenient for the participant. Participants will also be asked for help in inviting other family members to participate. No family member will be contacted without the permission and assistance of another participating family member.

For information on a related study, please follow this link:

http://clinicaltrials.gov/show/NCT00260182

  Eligibility

Ages Eligible for Study:   18 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Families that have at least TWO ADULT SIBLINGS (brother/brother; sister/sister; brother/sister) who have experienced major depression.
  • Depression must be RECURRENT (more than one episode).
  • Depression must have started at age 30 or less in one sibling, and at age 40 or less in the other sibling.

Exclusion Criteria:

  • Participants cannot have Bipolar I (manic-depressive) disorder or schizophrenia.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00005914

Locations
United States, Illinois
Rush Presbyterian - Saint Luke's Med Ctr
Chicago, Illinois, United States, 60612
United States, Iowa
Univ of Iowa Hosp and Clinic
Iowa City, Iowa, United States, 52242
United States, Maryland
Johns Hopkins University
Baltimore, Maryland, United States, 21287-7381
United States, New York
New York State Psychiatric Institute / Columbia Univ
New York, New York, United States, 10032
United States, Pennsylvania
Univ of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104-2648
Univ of Pittsburgh / Western Psychiatric Inst and Clinic
Pittsburgh, Pennsylvania, United States, 15213
Sponsors and Collaborators
Investigators
Principal Investigator: Myrna Weissman
Principal Investigator: J Raymond DePaulo
Principal Investigator: William Scheftner
Principal Investigator: Raymond Crowe
Principal Investigator: Douglas Levinson
Principal Investigator: George Zubenko
  More Information

Additional Information:
No publications provided

ClinicalTrials.gov Identifier: NCT00005914     History of Changes
Other Study ID Numbers: R01 MH061686-01, R01 MH60912, R01 MH59552, R01 MH59541, R01 MH59542, R01 MH61686, R01 MH60866, DNBBS 7G-GRR
Study First Received: June 15, 2000
Last Updated: December 16, 2009
Health Authority: United States: Federal Government

Keywords provided by National Institute of Mental Health (NIMH):
Depression
Depressive Disorder
Family
Genes
Genetic Techniques
Genetics
Linkage (Genetics)
Nuclear Family
Recurrence
Severity of Illness Index

Additional relevant MeSH terms:
Depression
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders

ClinicalTrials.gov processed this record on April 17, 2014