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| Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
| Information provided by: | National Heart, Lung, and Blood Institute (NHLBI) |
| ClinicalTrials.gov Identifier: | NCT00005250 |
Purpose
To screen by electrocardiography the entire population of 1,400 individuals in seven Amish Mennonite communities in order to perform genetic linkage studies of long QT syndrome (LQTS).
| Condition |
|
Heart Diseases Cardiovascular Diseases Tachycardia, Ventricular Ventricular Fibrillation Long QT Syndrome |
| Genetics Home Reference related topics: | Andersen-Tawil syndrome Brugada syndrome Jervell and Lange-Nielsen syndrome Romano-Ward syndrome short QT syndrome |
| MedlinePlus related topics: | Heart Diseases |
| Study Type: | Observational |
| Study Design: | Natural History |
| Study Start Date: | January 1990 |
| Estimated Study Completion Date: | December 1992 |
BACKGROUND:
LQTS is a severe heart disorder leading to sudden death due to ventricular tachycardia or ventricular fibrillation. The syndrome segregated as a Mendelian recessive in the highly inbred population under study and resulted in the sudden death of several members of the population.
DESIGN NARRATIVE:
The entire population was screened to identify cases of LQTS. In addition, 29 obligate heterozygotes were studied by 24-hour Holter monitoring to determine whether these gene carriers had any subtle phenotypes. The data were subjected to complex segregation and linkage analysis to establish the mode of inheritance and penetrance of LQTS.
Eligibility
| Genders Eligible for Study: | Male |
| Accepts Healthy Volunteers: | No |
No eligibility criteria
Contacts and Locations More Information
| Study ID Numbers: | 1132 |
| First Received: | May 25, 2000 |
| Last Updated: | June 23, 2005 |
| ClinicalTrials.gov Identifier: | NCT00005250 |
| Health Authority: | United States: Federal Government |
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