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Lifestyle and Chronic Disease in College Alumni (Harvard Alumni Health Study)

This study has been completed.

Sponsored by: National Heart, Lung, and Blood Institute (NHLBI)
Information provided by: National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier: NCT00005169
  Purpose

To monitor the relationship of lifestyle variables, particularly exercise, to cardiovascular mortality, all-cause mortality, projected longevity and aging, and cardiovascular morbidity in a large cohort of college graduates. To assess changing patterns of exercise, cigarette smoking, body weight, and blood pressure between the 1960s and 1990s for relationship to cardiovascular morbidity and mortality.


Condition
Cardiovascular Diseases
Heart Diseases
Coronary Disease
Hypertension
Cerebrovascular Accident

MedlinePlus related topics:   Coping with Chronic Illness    Heart Diseases    High Blood Pressure   

U.S. FDA Resources

Study Type:   Observational
Study Design:   Natural History

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date:   September 1984
Estimated Study Completion Date:   June 2000

Show detailed description  Show Detailed Description

  Eligibility
Ages Eligible for Study:   65 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Criteria

No eligibility criteria

  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00005169

Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)

Investigators
Investigator:     Ralph Paffenbarger     Stanford University    
  More Information


Publications:
Paffenbarger RS Jr, Wing AL, Hyde RT, Jung DL. Physical activity and incidence of hypertension in college alumni. Am J Epidemiol. 1983 Mar;117(3):245-57.
 
Whittemore AS, Paffenbarger RS Jr, Anderson K, Halpern J. Early precursors of pancreatic cancer in college men. J Chronic Dis. 1983;36(3):251-6.
 
Paffenbarger RS Jr: Exercise in the Primary Prevention of Coronary Heart Disease. In: Heart Disease and Rehabilitation, M Pollock (Ed). New York: John Wiley & Sons, 2nd Ed., 1986.
 
Paffenbarger RS Jr, Hyde RT. Exercise in the prevention of coronary heart disease. Prev Med. 1984 Jan;13(1):3-22. Review.
 
Paffenbarger RS Jr, Hyde RT, Wing AL, Steinmetz CH. A natural history of athleticism and cardiovascular health. JAMA. 1984 Jul 27;252(4):491-5.
 
Paffenbarger RS Jr, Hyde RT, Jung DL, Wing AL: Epidemiology of Exercise and Coronary Heart Disease. In: Symposium on Cardiac Rehabilitation, B Franklin (Ed). Philadelphia, PA: WB Saunders. Clinics in Sports Medicine 3:297-318, 1984
 
Whittemore AS, Paffenbarger RS Jr, Anderson K, Lee JE. Early precursors of urogenital cancers in former college men. J Urol. 1984 Dec;132(6):1256-61.
 
Whittemore AS, Paffenbarger RS Jr, Anderson K, Lee JE. Early precursors of site-specific cancers in college men and women. J Natl Cancer Inst. 1985 Jan;74(1):43-51.
 
Paffenbarger RS Jr: Physical Activity as a Defense Against Coronary Heart Disease. In: Coronary Heart Disease, WE Connor and JD Bristow (Eds). Philadelphia: JB Lippincott Company, 1985
 
Powell KE, Paffenbarger RS Jr. Workshop on Epidemiologic and Public Health Aspects of Physical Activity and Exercise: a summary. Public Health Rep. 1985 Mar-Apr;100(2):118-26.
 
Paffenbarger RS Jr, Hyde RT: Exercise in the Primary Prevention of Ischemic Heart Disease. In: Current Therapy in Sports Medicine 1985-1986, RP Welsh and RJ Shephard (Eds.), St. Louis: CV Mosby Company, 1985
 
Spaulding RB (Ed), Paffenbarger RS Jr, Cooper KH, Fielding JE: Dialogue III - Health Promotion/Disease Prevention. Harvard Public Health Alumni Bulletin, p. 4-40, Spring 1985
 
Sasco AJ, Paffenbarger RS Jr. Measles infection and Parkinson's disease. Am J Epidemiol. 1985 Dec;122(6):1017-31.
 
Curfman GD, Thomas GS, Paffenbarger RS Jr: Physical Activity and Primary Prevention of Cardiovascular Disease. In: Cardiovascular Clinics (Symposium on Preventive Cardiology and Cardiac Rehabilitation), GD Curfman, A Leaf (Eds). Volume 3, Number 2:203-222. Philadelphia, WB Saunders Company, May 1985
 
Whittemore AS, Zheng S, Wu A, Wu M, Fingar T, Jiao D, Ling C, Bao J, Henderson BE, Paffenbarger RS: Colorectal Cancer in Chinese and Chinese-Americans. NCI Monograph, 69:43-46, 1985
 
Blair SN, Haskell WL, Ho P, Paffenbarger RS Jr, Vranizan KM, Farquhar JW, Wood PD. Assessment of habitual physical activity by a seven-day recall in a community survey and controlled experiments. Am J Epidemiol. 1985 Nov;122(5):794-804.
 
Paffenbarger RS Jr: Exercise in the Primary Prevention of Coronary Heart Disease. In: Heart Disease and Rehabilitation, M Pollock and DH Schmidt (Eds). New York: John Wiley & Sons, 2nd Ed., p. 349-367, 1986
 
Paffenbarger RS Jr, Hyde RT, Wing AL, Hsieh CC. Physical activity, all-cause mortality, and longevity of college alumni. N Engl J Med. 1986 Mar 6;314(10):605-13.
 
Paffenbarger RS Jr, Hyde RT, Hsieh CC, Wing AL. Physical activity, other life-style patterns, cardiovascular disease and longevity. Acta Med Scand Suppl. 1986;711:85-91. Review.
 
Paffenbarger RS Jr, Hyde RT, Wing AL, Hsieh CC: Cigarette Smoking and Cardiovascular Disease. IARC Sci Publ, 74:45-60, 1986
 
Paffenbarger RS Jr. Contributions of epidemiology to exercise science and cardiovascular health. Med Sci Sports Exerc. 1988 Oct;20(5):426-38. Review.
 
Kohl HW 3rd, Powell KE, Gordon NF, Blair SN, Paffenbarger RS Jr. Physical activity, physical fitness, and sudden cardiac death. Epidemiol Rev. 1992;14:37-58. Review. No abstract available.
 
Paffenbarger RS Jr, Lee IM, Wing AL. The influence of physical activity on the incidence of site-specific cancers in college alumni. Adv Exp Med Biol. 1992;322:7-15. Review. No abstract available.
 
Lee IM, Paffenbarger RS Jr. Change in body weight and longevity. JAMA. 1992 Oct 21;268(15):2045-9.
 
Blair SN, Kohl HW, Gordon NF, Paffenbarger RS Jr. How much physical activity is good for health? Annu Rev Public Health. 1992;13:99-126. Review.
 
Lee IM, Paffenbarger RS Jr, Hsieh CC. Time trends in physical activity among college alumni, 1962-1988. Am J Epidemiol. 1992 Apr 15;135(8):915-25.
 
Hsieh CC, Maisonneuve P, Boyle P, Macfarlane GJ, Roberston C. Analysis of quantitative data by quantiles in epidemiologic studies: classification according to cases, noncases, or all subjects? Epidemiology. 1991 Mar;2(2):137-40.
 
Paffenbarger RS Jr, Jung DL, Leung RW, Hyde RT. Physical activity and hypertension: an epidemiological view. Ann Med. 1991 Aug;23(3):319-27.
 
Hsieh CC. The effect of non-differential outcome misclassification on estimates of the attributable and prevented fraction. Stat Med. 1991 Mar;10(3):361-73.
 
Helmrich SP, Ragland DR, Leung RW, Paffenbarger RS Jr. Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med. 1991 Jul 18;325(3):147-52.
 
Lee IM, Hsieh CC, Paffenbarger RS Jr. Exercise intensity and longevity in men. The Harvard Alumni Health Study. JAMA. 1995 Apr 19;273(15):1179-84.
 
Paffenbarger RS Jr, Kampert JB, Lee IM, Hyde RT, Leung RW, Wing AL. Changes in physical activity and other lifeway patterns influencing longevity. Med Sci Sports Exerc. 1994 Jul;26(7):857-65.
 
Lee IM, Manson JE, Hennekens CH, Paffenbarger RS Jr. Body weight and mortality. A 27-year follow-up of middle-aged men. JAMA. 1993 Dec 15;270(23):2823-8.
 
Paffenbarger RS Jr, Hyde RT, Wing AL, Lee IM, Jung DL, Kampert JB. The association of changes in physical-activity level and other lifestyle characteristics with mortality among men. N Engl J Med. 1993 Feb 25;328(8):538-45.
 
Paffenbarger RS Jr, Blair SN, Lee IM, Hyde RT. Measurement of physical activity to assess health effects in free-living populations. Med Sci Sports Exerc. 1993 Jan;25(1):60-70.
 
Helmrich SP, Ragland DR, Paffenbarger RS Jr. Prevention of non-insulin-dependent diabetes mellitus with physical activity. Med Sci Sports Exerc. 1994 Jul;26(7):824-30. Review.
 
Paffenbarger RS Jr, Lee IM, Leung R. Physical activity and personal characteristics associated with depression and suicide in American college men. Acta Psychiatr Scand Suppl. 1994;377:16-22.
 
Lee IM, Paffenbarger RS Jr. Do physical activity and physical fitness avert premature mortality? Exerc Sport Sci Rev. 1996;24:135-71. Review. No abstract available.
 
Paffenbarger RS Jr, Kampert JB, Lee IM. Physical activity and health of college men: longitudinal observations. Int J Sports Med. 1997 Jul;18 Suppl 3:S200-3.
 
Paffenbarger RS Jr, Lee IM, Kampert JB. Physical activity in the prevention of non-insulin-dependent diabetes mellitus. World Rev Nutr Diet. 1997;82:210-8. Review. No abstract available.
 
Sahi T, Paffenbarger RS Jr, Hsieh CC, Lee IM. Body mass index, cigarette smoking, and other characteristics as predictors of self-reported, physician-diagnosed gallbladder disease in male college alumni. Am J Epidemiol. 1998 Apr 1;147(7):644-51.
 
Lee IM, Paffenbarger RS Jr. Associations of light, moderate, and vigorous intensity physical activity with longevity. The Harvard Alumni Health Study. Am J Epidemiol. 2000 Feb 1;151(3):293-9.
 
Cole SR, Kawachi I, Sesso HD, Paffenbarger RS, Lee IM. Sense of exhaustion and coronary heart disease among college alumni. Am J Cardiol. 1999 Dec 15;84(12):1401-5.
 
Sesso HD, Paffenbarger RS, Ha T, Lee IM. Physical activity and cardiovascular disease risk in middle-aged and older women. Am J Epidemiol. 1999 Aug 15;150(4):408-16.
 
Lee IM, Paffenbarger RS Jr. Life is sweet: candy consumption and longevity. BMJ. 1998 Dec 19-26;317(7174):1683-4. No abstract available.
 
Lee IM, Paffenbarger RS Jr. Physical activity and stroke incidence: the Harvard Alumni Health Study. Stroke. 1998 Oct;29(10):2049-54.
 
Lee IM, Sesso HD, Paffenbarger RS Jr. Physical activity and coronary heart disease risk in men: does the duration of exercise episodes predict risk? Circulation. 2000 Aug 29;102(9):981-6.
 
Sesso HD, Paffenbarger RS Jr, Lee IM. Physical activity and coronary heart disease in men: The Harvard Alumni Health Study. Circulation. 2000 Aug 29;102(9):975-80.
 
Sesso HD, Paffenbarger RS Jr, Lee IM. Alcohol consumption and risk of prostate cancer: The Harvard Alumni Health Study. Int J Epidemiol. 2001 Aug;30(4):749-55.
 
Sesso HD, Paffenbarger RS, Lee IM. Comparison of National Death Index and World Wide Web death searches. Am J Epidemiol. 2000 Jul 15;152(2):107-11.
 

Study ID Numbers:   1043
First Received:   May 25, 2000
Last Updated:   June 23, 2005
ClinicalTrials.gov Identifier:   NCT00005169
Health Authority:   United States: Federal Government

Study placed in the following topic categories:
Heart Diseases
Cerebral Infarction
Myocardial Ischemia
Stroke
Vascular Diseases
Central Nervous System Diseases
Ischemia
Brain Diseases
Cerebrovascular Disorders
Coronary Disease
Brain Ischemia
Chronic Disease
Brain Infarction
Infarction
Hypertension

Additional relevant MeSH terms:
Nervous System Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on November 20, 2008

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