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Phase II Study of Calcitonin for Tumoral Calcinosis
This study has been completed.
Study NCT00004358   Information provided by National Center for Research Resources (NCRR)
First Received: October 18, 1999   Last Updated: June 23, 2005   History of Changes

October 18, 1999
June 23, 2005
November 1992
 
 
 
Complete list of historical versions of study NCT00004358 on ClinicalTrials.gov Archive Site
 
 
 
Phase II Study of Calcitonin for Tumoral Calcinosis
 

OBJECTIVES: I. Determine whether intermittent, long-term, subcutaneous administration of calcitonin increases phosphaturia, reduces hyperphosphatemia, and increases intact parathyroid hormone levels in patients with tumoral calcinosis.

II. Determine whether calcitonin reduces or prevents tumor recurrence. III. Determine whether hyperphosphatemia abolishes the normal circadian pattern of serum phosphorus.

IV. Determine how repetitive calcitonin administration alters the biochemical markers of bone metabolism in osteopenic patients with tumoral calcinosis.

PROTOCOL OUTLINE: Patients are treated with subcutaneous injections of salmon calcitonin every 3 weeks. Ondansetron premedication and intravenous hydration are also administered.

Patients are followed for disease progression and tumor recurrence.

Phase II
Interventional
Treatment
Calcinosis
Drug: calcitonin
 
 

*   Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
 
Completed
9
 
 

PROTOCOL ENTRY CRITERIA:

--Disease Characteristics-- Histologically confirmed tumoral calcinosis --Prior/Concurrent Therapy-- Prior surgical resection of calcinotic lesion required

Both
 
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00004358
 
199/11925, NU-477
National Center for Research Resources (NCRR)
Children's Memorial Hospital
Study Chair: Craig B. Langman Children's Memorial Hospital
National Center for Research Resources (NCRR)
December 2003

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP