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Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia

This study has been completed.
Sponsor:
Collaborator:
University of California, San Diego
Information provided by:
National Center for Research Resources (NCRR)
ClinicalTrials.gov Identifier:
NCT00004353
First received: October 18, 1999
Last updated: July 9, 2008
Last verified: April 2002
  Purpose

OBJECTIVES: I. Study the metabolism of pyruvate and related problems in patients with lactic acidemia.

II. Define the nature of the metabolic defect.


Condition
Mitochondrial Myopathy
MELAS Syndrome
Lactic Acidosis

Study Type: Observational

Resource links provided by NLM:


Further study details as provided by National Center for Research Resources (NCRR):

Estimated Enrollment: 35
Study Start Date: December 1978
Detailed Description:

PROTOCOL OUTLINE: Patients fast for 6 hours. Glucagon IM is administered after the 6 hour fast. Glucose level is measured at 0, 15, 30, 45, 60, and 90 minutes.

In children of sufficient size, alanine and lactic acid should also be measured at each or most of these time points.

Fasting continues for at least 18 hours. Glucagon IM is administered again at end of fast. Glucose level is measured at time 0, 15, 30, 45, 60, and 90 minutes.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

PROTOCOL ENTRY CRITERIA:

  • Diagnostically documented elevation in lactate, pyruvate, and/or alanine levels in lactic acidemia patients
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00004353

Locations
United States, California
University of California San Diego Medical Center
San Diego, California, United States, 92103-8757
Sponsors and Collaborators
University of California, San Diego
Investigators
Study Chair: Richard H. Haas University of California, San Diego
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00004353     History of Changes
Other Study ID Numbers: NCRR-M01RR00827-0071, UCSD-071
Study First Received: October 18, 1999
Last Updated: July 9, 2008
Health Authority: United States: Federal Government

Keywords provided by National Center for Research Resources (NCRR):
MELAS syndrome
inborn errors of metabolism
lactic acidosis
mitochondrial myopathy
rare disease

Additional relevant MeSH terms:
Mitochondrial Myopathies
Acidosis
Acidosis, Lactic
MELAS Syndrome
Syndrome
Acid-Base Imbalance
Brain Diseases
Brain Diseases, Metabolic
Brain Diseases, Metabolic, Inborn
Cardiovascular Diseases
Central Nervous System Diseases
Cerebral Small Vessel Diseases
Cerebrovascular Disorders
Disease
Genetic Diseases, Inborn
Metabolic Diseases
Metabolism, Inborn Errors
Mitochondrial Diseases
Mitochondrial Encephalomyopathies
Muscular Diseases
Musculoskeletal Diseases
Nervous System Diseases
Neuromuscular Diseases
Pathologic Processes
Vascular Diseases

ClinicalTrials.gov processed this record on November 25, 2014