Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Stage III Ovarian Cancer

DISEASE CHARACTERISTICS:

• Histologically proven optimally debulked stage III ovarian or primary peritoneal carcinoma

  • Any of the following subtypes:

    • Serous adenocarcinoma
    • Mucinous adenocarcinoma
    • Clear cell carcinoma
    • Transitional cell carcinoma
    • Endometrioid adenocarcinoma
    • Undifferentiated adenocarcinoma
    • Mixed epithelial adenocarcinoma
    • Adenocarcinoma, not otherwise specified
• No ovarian carcinoma of low malignant potential (borderline)
• Concurrent superficial endometrial or cervical carcinoma allowed if ovarian carcinoma more life threatening or limiting

• Must have undergone appropriate primary surgical staging and debulking for ovarian carcinoma and have less than 1 cm of residual disease

  • No more than 8 weeks since prior surgical debulking
• Must have Hickman catheter in place or be eligible for placement
• No CNS involvement

PATIENT CHARACTERISTICS:

Age:

• Over 18

Performance status:

• GOG 0 or 1

Life expectancy:

• Not specified

Hematopoietic:

• Absolute neutrophil count at least 1,500/mm^3
• Platelet count at least 100,000/mm^3

Hepatic:

• Bilirubin no greater than 1.5 mg/dL
• SGOT or SGPT no greater than 2 times upper limit of normal
• No active hepatitis

Renal:

• Creatinine no greater than 1.5 mg/dL OR
• Creatinine clearance at least 60 mL/min
• No renal failure
• Curatively treated ureteral obstruction allowed if above creatinine measurements met

Cardiovascular:

• No congestive heart failure
• No myocardial infarction within the past 6 months
• No significant arrhythmias requiring medication
• No poorly controlled systolic or diastolic hypertension (diastolic blood pressure consistently greater than 100 mm Hg)

Pulmonary:

• No significant nonneoplastic pulmonary disease

Other:

• No other malignancy within the past 5 years except basal cell or squamous cell skin cancer or carcinoma in situ of the cervix
• HIV negative

• No other severe medical or psychiatric illness including, but not limited to the following:

  • Acute infection
  • Active peptic ulcer disease
  • Uncontrolled diabetes mellitus
  • Prior hospitalization for psychiatric illness, including severe depression or psychosis
  • Concurrent alcohol or drug abuse

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• Not specified

Chemotherapy:

• No prior chemotherapy for this malignancy

Endocrine therapy:

• Not specified

Radiotherapy:

• No radiotherapy to greater than 25% of bone marrow

Surgery:

• See Disease Characteristics