Inclusion Criteria

Concurrent Medication:

Allowed:

• Inhaled pentamidine following completion of the inpatient pharmacokinetic portion of the study.

Patients must have:

• HIV-1 infection.
• CD4 count 200 - 500 cells/mm3.
• Maintenance on AZT for at least 6 weeks.
• No active opportunistic infections.
• Ability to swallow numerous tablets without difficulty.
• Ability to have blood samples drawn.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

• Acute medical problems, including opportunistic infections (such as active cryptococcosis, pneumocystis carinii, herpes zoster, histoplasmosis, CMV) and nonopportunistic diseases (liver and renal disease, orthostatic hypotension, hypertension, progressive multifocal leukoencephalopathy, lymphoma, Kaposi's sarcoma, or other malignancy).
• Clinically significant hypersensitivity to piperazine type drugs (Antepar, Stelazine, and U-87201E).
• Negative EMIT drug screen or equivalent for drugs of abuse.

Concurrent Medication:

Excluded:

• Antiretroviral agents other than AZT.
• Primary or secondary prophylactic medications for opportunistic infections (inhaled pentamidine is permitted following completion of the inpatient pharmacokinetic portion of the study).

Patients with the following prior conditions are excluded:

• History of clinically significant nervous system or muscle disease, seizure disorder, AIDS dementia, or psychotic disorder that might impair study compliance.
• History of clinically significant cardiovascular, renal, hepatic, cardiac, pulmonary, endocrine, hematologic, vascular, or collagen disease.

Prior Medication:

Excluded:

• Prior U-87201E or other non-nucleoside reverse transcriptase inhibitors (nevirapine, TIBO, L-drugs, and HEPT).
• Antiretroviral agents (other than AZT) or immunomodulating agents within 15 days prior to study entry.
• Primary prophylactic drugs within 15 days prior to study entry.
• Any known enzyme-inducing drug or any enzyme-inhibiting agents, such as ketoconazole, fluconazole, rifampin, isoniazid, and cimetidine, within 15 days prior to study entry.
• Any investigational medication within 15 days prior to study entry. Unwilling to comply with safer sex practices. Active substance abuse. Alcohol consumption during the inpatient pharmacokinetic portion of the study.