Inclusion Criteria

Patients must have:

• HIV-1 infection.
• AIDS.
• Chronic mucocutaneous herpes simplex virus (HSV) infection, with one or more lesions unresponsive to oral acyclovir therapy.
• No uncontrolled infections other than HSV.
• Sufficient mental status to understand the purpose of the study and to comply with study requirements.
• Sufficient general health to be an outpatient and to come to the clinic for required follow-up visits.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

• Known hypersensitivity or allergy to citrus fruits, black currant berries, and rose hips.
• Any disease condition that, in the opinion of the investigator, would interfere with evaluation of the study drug, affect patient compliance, or place the patient at increased risk.

Concurrent Medication:

Excluded:

• Other unapproved investigational new drugs.
• Concurrent other therapy for herpes simplex virus (HSV) infection or medications with known activity against HSV.

Required:

• A minimum of 10 days of prior oral acyclovir (at least 1 g daily) or 10 days of prior intravenous acyclovir (15 mg/kg daily).