Study of the Effects of Temperature on Metabolism in Human Muscle

This study has been completed.
Sponsor:
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT00001753
First received: November 3, 1999
Last updated: March 3, 2008
Last verified: August 1999
  Purpose

This study will examine the role of temperature in changing energy metabolism in human muscle. In order to do this, researchers will use magnetic resonance imaging (MRI) to provide information about how parts of muscle operate during exercise.

Magnetic resonance imaging (MRI) is a diagnostic tool that creates high quality images of the human body without the use of X-ray (radiation). In this study, MRI will be used to measure the temperature and energy level of specific muscles during rest and exercise. In addition, the muscles being tested will be heated and cooled to see if temperature directly affects levels of energy in muscle.


Condition Intervention Phase
Healthy
Procedure: Magnetic resonance imaging
Phase 1

Study Type: Interventional
Study Design: Endpoint Classification: Safety Study
Primary Purpose: Treatment
Official Title: Study of Temperature Effects on Skeletal Muscle Aerobic Energy Metabolism

Resource links provided by NLM:


Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 17
Study Start Date: September 1998
Estimated Study Completion Date: November 2000
Detailed Description:

This study will examine the role of temperature in modulating aspects of energy metabolism in human skeletal muscle. Tests will be conducted at rest and during concentric dorsiflexion exercise of the Tibialis anterior (TA) muscle using an existing custom-designed dynamometer in conjunction with mild local heating and cooling. Magnetic resonance spectroscopy (MRS), performed in a 4-tesla whole-body NMR system, will be used to non-invasively measure muscle temperature and energy-state. Specifically these tests will assess the extent to which temperature changes occur during aerobic exercise and how small temperature changes affect mitochondrial function in-vivo.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Ages 18 to 50.

Male and female subjects.

Capable of giving informed consent.

Healthy normal volunteers.

No cardiac pacemaker of implantable defibrillator.

No aneurysm clip.

No neural stimulator (e.g. TENS-unit).

No ear implant of any type.

No metal in the eye (e.g. from machining).

No implanted device (e.g. insulin pump, drug infusion device).

No metallic foreign body, shrapnel, or bullet.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00001753

Locations
United States, Maryland
National Heart, Lung and Blood Institute (NHLBI)
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00001753     History of Changes
Other Study ID Numbers: 980166, 98-H-0166
Study First Received: November 3, 1999
Last Updated: March 3, 2008
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Exercise
MRI
MRS
Normal Volunteer
Tibialix Anterior

ClinicalTrials.gov processed this record on July 24, 2014