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Tissue Acquisition for Molecular Diagnostics
This study has been completed.
Sponsored by: National Cancer Institute (NCI)
Information provided by: National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier: NCT00001580
  Purpose

Acquisition of fresh tumor and normal tissue samples are necessary for the preparation of cDNA libraries, microarray chips, and tissue specific probes, and proteomics development and validation. This protocol will allow acquisition of samples at the time of tissue sampling for surgery, diagnostic tests, or therapeutic phereses. These samples will be forwarded without patient identifiers, pathology reports, or other labels. Tissue pathology will be verified within the Laboratory of Pathology and samples used strictly for CGAP and Proteomic Initiative indications.


Condition
Neoplasm

MedlinePlus related topics: Cancer
U.S. FDA Resources
Study Type:
Observational
Official Title:
Tissue Acquisition for Molecular Diagnostics

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment:
50
Study Start Date:
June 1997
Estimated Study Completion Date:
March 2003

Detailed Description:

Acquisition of fresh tumor and normal tissue samples is necessary for the preparation of cDNA libraries, microarray chips, tissue specific probes, and proteomics development and validation. This protocol will allow acquisition of patient samples at the time of tissue sampling for surgery, diagnostic tests, or therapeutic phereses. These samples will be forwarded without patient identifiers, pathology reports, or other labels. Tissue pathology will be verified within the Laboratory of Pathology and samples used strictly for CGAP and Proteomic Initiative indications.

  Eligibility
Genders Eligible for Study:
Both
Accepts Healthy Volunteers:
No
Criteria

INCLUSION CRITERIA:

All patients willing to sign the informed consent for whom tissue, blood or body fluids will be available are eligible.

Histopathologic diagnosis will be confirmed in the Laboratory of Pathology, National Cancer Institute and is not a criteria for inclusion.

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00001580

Locations
United States, Maryland
National Cancer Institute (NCI)
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Cancer Institute (NCI)
  More Information

Publications:
Emmert-Buck MR, Bonner RF, Smith PD, Chuaqui RF, Zhuang Z, Goldstein SR, Weiss RA, Liotta LA. Laser capture microdissection. Science. 1996 Nov 8;274(5289):998-1001.
Krizman DB, Chuaqui RF, Meltzer PS, Trent JM, Duray PH, Linehan WM, Liotta LA, Emmert-Buck MR. Construction of a representative cDNA library from prostatic intraepithelial neoplasia. Cancer Res. 1996 Dec 1;56(23):5380-3.
Emmert-Buck MR, Vocke CD, Pozzatti RO, Duray PH, Jennings SB, Florence CD, Zhuang Z, Bostwick DG, Liotta LA, Linehan WM. Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia. Cancer Res. 1995 Jul 15;55(14):2959-62.

Study ID Numbers:
970138, 97-C-0138
First Received:
November 3, 1999
Last Updated:
March 3, 2008
ClinicalTrials.gov Identifier:
NCT00001580  
Health Authority:
United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Molecular Diagnostics
Ovary
Tissue Acquisition
cDNA Library
CGAP

Additional relevant MeSH terms:
Neoplasms

ClinicalTrials.gov processed this record on January 09, 2009



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