Establishment of Normal Breast Epithelial Cell Lines From Patients at High Risk for Breast Cancer
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Purpose
Women who are at high risk for breast cancer, either because of linkage to high risk breast and ovarian cancer families, or because of a carcinoma in the opposite breast, will be studied. Women will have a physical examination and mammography to ensure that no breast abnormalities are present. Eligible women will undergo biopsy of the breast to obtain normal breast tissue. Short-term cell cultures will be established from this tissue and early passages of the short-term cell lines will be stored. A bank of high risk normal mammary epithelial cells will be established. To further characterize the mammary epithelial cells in this population of women, cell cultures will subsequently be analyzed for their growth and metabolic properties, sensitivity to chemopreventive agents, steroid receptor characteristics, oncogene expression and regulation, and genetic changes.
| Condition |
|---|
|
Breast Neoplasm Hereditary Neoplastic Syndrome |
| Study Type: | Observational |
| Official Title: | Establishment of Normal Breast Epithelial Cell Lines From Patients at High Risk for Breast Cancer |
| Estimated Enrollment: | 50 |
| Study Start Date: | January 1996 |
| Estimated Study Completion Date: | November 2001 |
Women who are at high risk for breast cancer, either because of linkage to high risk breast and ovarian cancer families, or because of a carcinoma in the opposite breast, will be studied. Women will have a physical examination and mammography to ensure that no breast abnormalities are present. Eligible women will undergo biopsy of the breast to obtain normal breast tissue. Short-term cell cultures will be established from this tissue and early passages of the short-term cell lines will be stored. A bank of high risk normal mammary epithelial cells will be established. To further characterize the mammary epithelial cells in this population of women, cell cultures will subsequently be analyzed for their growth and metabolic properties, sensitivity to chemopreventive agents, steroid receptor characteristics, oncogene expression and regulation, and genetic changes.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Women at high risk for breast cancer, either because they are a member of a high risk breast or ovarian cancer family, or because of a carcinoma of the opposite breast.
Normal mammogram within past 3 months.
No suspicious breast or axillary lesions on physical examination.
No major cardiopulmonary, hepatic or renal disorders.
Contacts and Locations More Information
Publications:
| ClinicalTrials.gov Identifier: | NCT00001496 History of Changes |
| Other Study ID Numbers: | 960026, 96-C-0026 |
| Study First Received: | November 3, 1999 |
| Last Updated: | March 3, 2008 |
| Health Authority: | United States: Federal Government |
Keywords provided by National Institutes of Health Clinical Center (CC):
|
BRCA-1 Familial Breast Cancer Breast Cell Culture High Risk |
Additional relevant MeSH terms:
|
Breast Neoplasms Neoplasms Neoplastic Syndromes, Hereditary Neoplasms by Site |
Breast Diseases Skin Diseases Genetic Diseases, Inborn |
ClinicalTrials.gov processed this record on May 22, 2013