Neuropsychiatric Evaluation of Healthy Volunteers and Adults With Schizophrenia

This study has been completed.
Sponsor:
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT00001323
First received: November 3, 1999
Last updated: March 3, 2008
Last verified: August 2005
  Purpose

The purpose of this study is to evaluate the cognitive processes of participants with schizophrenia, participants with nervous system and mental disorders, and healthy volunteers.

Participants in this study will undergo cognitive tests of attention, memory, attention. Participants with attention deficit hyperactivity disorder (ADHD), traumatic brain injury (TBI), bipolar disorder, and Alzheimer's disease (AD) will be compared with participants with schizophrenia. A group of healthy adults and children will undergo cognitive tests to further delineate the degree of impairment in schizophrenia and neurological disorder participants.


Condition
Brain Injury
Dementia
Healthy
Mental Disorder
Schizophrenia

Study Type: Observational
Official Title: Neuropsychiatric Evaluation of Normal Subjects and Psychiatric and Neurologic Contrast Groups

Resource links provided by NLM:


Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 810
Study Start Date: August 1992
Estimated Study Completion Date: August 2005
Detailed Description:

In this study, we propose to administer cognitive tests to schizophrenic patients and to neurologic patients who will serve as contrast groups for neuropsychological studies of patients with schizophrenia. These include studies of Alzheimers disease to dissociate size and organization of lexicon and ADHD to understand error patterns on CPT-type tests of attention and vigilance. However, the majority of studies will examine schizophrenia in relation to normal controls.

In addition, we propose to obtain test results from a local sample of normal subjects of varying ages and educational backgrounds to further delineate degree of impairment in these clinical groups. As well as assessing adults we wish to assess normal children. In particular, we wish to identify in children the size of their lexicon and their degree of semantic organization within their lexicon.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

INCLUSION CRITERIA

English-speaking adults between ages 21 to 65, in good health and free from significant substance abuse.

Children between ages 4 to 20 must not have a history of special education, using psychotropic medication in long-term counseling or with a history of seizures, head injury or CNS infections.

Normal controls will be recruited and screened for exclusionary morbidity by interview (e.g., no history of contact with mental health professionals, no history of diagnosable alcohol and/or substance abuse).

Normal controls will be recruited from building employees, local universities, from NIMH rosters, and the general public.

EXCLUSION CRITERIA

Excluded are adults with histories of dementing illness, movement disorder, affective disorders, developmental and/or acquired brain injury. Diagnoses will be made by review of medical records, interview, examination, and in the case of psychiatric diagnoses, a structured interview by SCID.

Advertisement will make clear that the subjects will be asked questions about family psychiatric history and their own history or psychiatric disorder, substance abuse, and neurological disease. Only if the subject answers these negatively will he or she participate in this study.

  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00001323

Locations
United States, Maryland
National Institute of Mental Health (NIMH)
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00001323     History of Changes
Other Study ID Numbers: 920262, 92-M-0262
Study First Received: November 3, 1999
Last Updated: March 3, 2008
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Cognition
Neuropsychology
Neuropsychological Tests
Neurological Exam
Psychiatric
Attention
Schizophrenic
Schizoaffective
Working Memory
Memory

Additional relevant MeSH terms:
Mental Disorders
Psychotic Disorders
Dementia
Schizophrenia
Brain Injuries
Wounds and Injuries
Schizophrenia and Disorders with Psychotic Features
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Delirium, Dementia, Amnestic, Cognitive Disorders
Craniocerebral Trauma
Trauma, Nervous System

ClinicalTrials.gov processed this record on August 21, 2014