Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders

This study is currently recruiting participants.

Verified by National Institutes of Health Clinical Center (CC), December 2008

First Received: November 3, 1999 Last Updated: June 9, 2009 History of Changes

Sponsored by:	National Institute of Neurological Disorders and Stroke (NINDS)
Information provided by:	National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:	NCT00001178

Purpose

The Cognitive Neuroscience Section of the National Institute of Neurological Disorders and Stroke proposes to continue its cross-sectional and longitudinal studies of cerebral metabolism in frontal lobe dementias and atypical basal ganglia disorders. These studies include repeated assessments of neuropsychological and brain anatomical and metabolic function in subjects with these important and possibly related brain disorders.

Condition
Alzheimer's Disease Dementia Down's Syndrome

Study Type:	Observational
Official Title:	Regional Cerebral Utilization of Glucose in Patients With a Diagnosis of Frontal Lobe Dementia, Atypical Parkinsonian Disorder, and Other Basal Ganglia Disorders

Resource links provided by NLM:

Genetics Home Reference related topics: Alzheimer disease Down syndrome familial paroxysmal nonkinesigenic dyskinesia

MedlinePlus related topics: Alzheimer's Disease Dementia Down Syndrome Neurologic Diseases

U.S. FDA Resources

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment:	675
Study Start Date:	January 1981
Estimated Study Completion Date:	July 1985
Estimated Primary Completion Date:	July 1985 (Final data collection date for primary outcome measure)

Detailed Description:

Objective

To continue the cross-sectional and longitudinal studies performed by the Cognitive Neuroscience Section of NINDS on the neuroanatomy, cerebral metabolism, neuropsychology, and genetics of frontotemporal dementia, corticobasal syndrome, and related brain disorders.

Study population

Frontal lobe dementias and atypical basal ganglia disorders including frontotemporal dementia, corticobasal syndrome, and related brain disorders.

Design

A cross-sectional assessment of neuropsychological, brain anatomical and metabolic function, and genetic measures in subjects with these disorders.

Outcome measures

MRI, FDG-PET, neuropsychological and clinical tests, genetics, and neuropathology.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Subjects will be recruited from the NIH referral center, neurological and psychiatric clinics, from self or family referral in response to advertisements or from private physicians. Healthy volunteers will include subjects who are considered aT-risk for the development of FTD or CBS and subjects who serve as normal controls matched for key characteristics with the patients.

INCLUSION CRITERIA FOR PATIENTS:

Diagnosis of possible / probable FTD or CBS
Caregiver willing and able to accept the responsibilities involved in the study

EXCLUSION CRITERIA:

Pregnant women. Women of childbearing potential will be screened by history for the possibility of pregnancy and undergo a urine pregnancy test.

These women will be excluded from the imaging portions of the protocol.

Behavioral symptoms that would preclude the gathering of data for the study
Other medical or social condition that would preclude participation in the opinion of the investigators

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00001178

Contacts

Contact: Patient Recruitment and Public Liaison Office	(800) 411-1222	prpl@mail.cc.nih.gov
Contact: TTY	1-866-411-1010

Locations

United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike	Recruiting
Bethesda, Maryland, United States, 20892

Sponsors and Collaborators

National Institute of Neurological Disorders and Stroke (NINDS)

More Information

Additional Information:

NIH Clinical Center Detailed Web Page This link exits the ClinicalTrials.gov site

Publications:

Schwartz M, Creasey H, Grady CL, DeLeo JM, Frederickson HA, Cutler NR, Rapoport SI. Computed tomographic analysis of brain morphometrics in 30 healthy men, aged 21 to 81 years. Ann Neurol. 1985 Feb;17(2):146-57.

Schlageter NL, Horwitz B, Creasey H, Carson R, Duara R, Berg GW, Rapoport SI. Relation of measured brain glucose utilisation and cerebral atrophy in man. J Neurol Neurosurg Psychiatry. 1987 Jun;50(6):779-85.

Duara R, Grady C, Haxby J, Ingvar D, Sokoloff L, Margolin RA, Manning RG, Cutler NR, Rapoport SI. Human brain glucose utilization and cognitive function in relation to age. Ann Neurol. 1984 Dec;16(6):703-13.

Study ID Numbers:	810010, 81-N-0010
Study First Received:	November 3, 1999
Last Updated:	June 9, 2009
ClinicalTrials.gov Identifier:	NCT00001178 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):

Alzheimer's Disease
Cerebral Metabolism
Cerebrospinal Fluid
Dementia of the Alzheimer Type
18-F-Fluoro-2-Deoxy-D-Glucose (FDG)
Magnetic Resonance Imaging

Positron Emission Tomography
X-Ray Computed Tomography (CT)
Senile Dementia
Down Syndrome
Trisomy 21

Study placed in the following topic categories:

Ganglion Cysts
Alzheimer Disease
Basal Ganglia Diseases
Chromosome Disorders
Central Nervous System Diseases
Trisomy
Brain Diseases
Neurodegenerative Diseases
Cognition Disorders
Mental Retardation
Delirium, Dementia, Amnestic, Cognitive Disorders
Genetic Diseases, Inborn

Movement Disorders
Mental Disorders
Abnormalities, Multiple
Deoxyglucose
Neurologic Manifestations
Parkinsonian Disorders
Down Syndrome
Congenital Abnormalities
Dementia
Neurobehavioral Manifestations
Delirium

Additional relevant MeSH terms:

Disease
Basal Ganglia Diseases
Alzheimer Disease
Nervous System Diseases
Chromosome Disorders
Central Nervous System Diseases
Brain Diseases
Neurodegenerative Diseases
Mental Retardation
Pathologic Processes
Delirium, Dementia, Amnestic, Cognitive Disorders
Genetic Diseases, Inborn

Movement Disorders
Mental Disorders
Syndrome
Abnormalities, Multiple
Neurologic Manifestations
Down Syndrome
Parkinsonian Disorders
Congenital Abnormalities
Dementia
Tauopathies
Neurobehavioral Manifestations

ClinicalTrials.gov processed this record on July 02, 2009