Women's Ischemia Syndrome Evaluation (WISE)

This study has been completed.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
University of Pittsburgh
ClinicalTrials.gov Identifier:
NCT00000554
First received: October 27, 1999
Last updated: April 3, 2014
Last verified: April 2014
  Purpose

To evaluate innovative diagnostic methods that will improve the diagnostic reliability of cardiovascular testing in evaluation of ischemic heart disease in women. Innovative approaches proposed include physiologic or functional measurements such as impaired metabolism, perfusion, or endothelial function as well as assessment of epicardial coronary arteries by angiography. Other objectives include developing safe, accurate, and cost effective diagnostic approaches for evaluating women with suspected ischemic heart disease, and determining the frequency of myocardial ischemia in the absence of significant epicardial coronary stenosis, as well as the frequency of non-ischemic or non-cardiac chest pain. A key aspect of the WISE study is to determine whether evidence of myocardial ischemia occurs in the absence of obstructive coronary disease.


Condition Intervention Phase
Angina Pectoris
Cardiovascular Diseases
Coronary Disease
Heart Diseases
Myocardial Ischemia
Procedure: Angiography, MRI, Dobutamine-Stress Echocardiography, PET,
Procedure: Myocardial Contrast Echo, Coronary Flow and Vasomotor Testing
Phase 3

Study Type: Interventional
Study Design: Primary Purpose: Diagnostic

Resource links provided by NLM:


Further study details as provided by University of Pittsburgh:

Study Start Date: May 2001
Study Completion Date: April 2007
Primary Completion Date: April 2007 (Final data collection date for primary outcome measure)
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   15 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Women over the age of 18 who have suspected ischemic heart disease.

  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00000554

Sponsors and Collaborators
University of Pittsburgh
Investigators
Investigator: Sheryl Kelsey University of Pittsburgh
Investigator: Carl Pepine University of Florida
Investigator: Steven Reis University of Pittsburgh
  More Information

Publications:

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: University of Pittsburgh
ClinicalTrials.gov Identifier: NCT00000554     History of Changes
Other Study ID Numbers: 98, U01HL064829
Study First Received: October 27, 1999
Last Updated: April 3, 2014
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Angina Pectoris
Cardiovascular Diseases
Myocardial Ischemia
Coronary Artery Disease
Coronary Disease
Heart Diseases
Ischemia
Vascular Diseases
Chest Pain
Pain
Signs and Symptoms
Arteriosclerosis
Arterial Occlusive Diseases
Pathologic Processes
Dobutamine
Cardiotonic Agents
Cardiovascular Agents
Therapeutic Uses
Pharmacologic Actions
Sympathomimetics
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Adrenergic beta-1 Receptor Agonists
Adrenergic beta-Agonists
Adrenergic Agonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Protective Agents

ClinicalTrials.gov processed this record on August 20, 2014