Hypertension Prevention Trial (HPT) Feasibility Study

This study has been completed.
Sponsor:
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:
NCT00000501
First received: October 27, 1999
Last updated: November 25, 2013
Last verified: April 2012
  Purpose

To test the feasibility and the efficacy of nutritional interventions in the primary prevention of hypertension in individuals predisposed to the development of hypertension; specifically, to test the hypothesis that reduction of weight and/or decreased sodium intake in obese individuals, or decreased sodium intake with or without increased potassium intake (in men and women, regardless of weight) would prevent the elevation of blood pressure and the incidence of hypertension.


Condition Intervention Phase
Cardiovascular Diseases
Heart Diseases
Hypertension
Obesity
Vascular Diseases
Behavioral: diet, sodium-restricted
Behavioral: diet, reducing
Drug: potassium
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Primary Purpose: Prevention

Resource links provided by NLM:


Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: September 1981
Study Completion Date: August 1986
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   25 Years to 49 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Men and women, ages 25 to 49. Diastolic blood pressure between 78 and 89 mm Hg. Free of major disease. Not on a special diet or antihypertensive medication at entry. Some mild to moderately obese subjects.

  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00000501

Sponsors and Collaborators
Investigators
Investigator: Nemat Borhani University of California, Davis
Investigator: Robert Jeffery University of Minnesota - Clinical and Translational Science Institute
Investigator: Herbert Langford University of Mississippi Medical Center
Investigator: Albert Oberman University of Alabama at Birmingham
Investigator: Ronald Prineas University of Minnesota - Clinical and Translational Science Institute
  More Information

Publications:
Hypertension Prevention Trial Research Group: Hypertension Prevention Trial--First Year Dietary Changes. In Strasser T, Ganten D, (Eds.). Mild Hypertension: From Drug Trials to Practice, New York, Raven Press, 1987.
Tonascia J, Donithan M, Tonascia S, et al for the Hypertension Prevention Trial Research Group: Hypertension Prevention Trial: Estimation of 24-hour Sodium and Potassium Excretion from Overnight Urine Collections. Baltimore, Maryland, Department of Biostatistics, Johns Hopkins University, Technical Report 703, 1989.

ClinicalTrials.gov Identifier: NCT00000501     History of Changes
Other Study ID Numbers: 20, R01HL026585-07
Study First Received: October 27, 1999
Last Updated: November 25, 2013
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Hypertension
Vascular Diseases

ClinicalTrials.gov processed this record on October 02, 2014