63 studies found for:    sickle cell anemia OR sickle cell disease OR hemoglobin S disease OR hemoglobin SS disease | Open Studies | United States | NIH, U.S. Fed
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Rank Status Study
1 Recruiting Bone Marrow Transplantation in Young Adults With Severe Sickle Cell Disease
Condition: Sickle Cell Disease
Intervention: Other: Biological: Bone Marrow Transplant
2 Unknown  Phase II Randomized Trial of Arginine Butyrate Plus Standard Local Therapy in Patients With Refractory Sickle Cell Ulcers
Conditions: Skin Ulcers;   Sickle Cell Anemia
Intervention: Drug: arginine butyrate
3 Recruiting Study to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain Crises
Condition: Sickle Cell Disease
Interventions: Drug: SelG1;   Drug: Placebo
4 Recruiting A Phase II Trial of Regadenoson in Sickle Cell Anemia
Condition: Sickle Cell Anemia
Interventions: Drug: Regadenoson;   Drug: Regadenoson Placebo
5 Recruiting Hydroxyurea to Prevent Brain Injury in Sickle Cell Disease
Conditions: Sickle Cell Disease;   Stroke
Interventions: Drug: Hydroxyurea;   Drug: Placebo
6 Recruiting Pharmacokinetics (PK) of Liquid Hydroxyurea in Pediatric Patients With Sickle Cell Anemia
Condition: Sickle Cell Anemia
Intervention: Drug: Hydroxyurea
7 Recruiting Treosulfan and Fludarabine Phosphate Before Donor Stem Cell Transplant in Treating Patients With Nonmalignant Inherited Disorders
Condition: Nonmalignant Neoplasm
Interventions: Drug: treosulfan;   Drug: fludarabine phosphate;   Biological: anti-thymocyte globulin;   Radiation: total-body irradiation;   Procedure: allogeneic bone marrow transplantation;   Procedure: peripheral blood stem cell transplantation;   Procedure: umbilical cord blood transplantation;   Drug: tacrolimus;   Drug: methotrexate;   Drug: cyclosporine;   Drug: mycophenolate mofetil;   Other: laboratory biomarker analysis
8 Recruiting Natural History of Sickle Cell Disease and Other Hemolytic Disorders
Conditions: Hemoglobin SC Disease;   Hematologic Diseases;   Sickle Cell Anemia;   Hemolytic Anemia
Intervention:
9 Unknown  Study of Clotrimazole and Hydroxyurea in Patients With Sickle Cell Syndromes
Condition: Sickle Cell Anemia
Interventions: Drug: clotrimazole;   Drug: hydroxyurea
10 Not yet recruiting Comparing Acute Pain Management Protocols for Patients With Sickle Cell Disease
Condition: Sickle Cell Disease
Interventions: Drug: Hydromorphone (Standardized, weight-based dosing);   Drug: Morphine Sulfate (Standardized, weight-based dosing);   Drug: Hydromorphone (Patient Specific dosing);   Drug: Morphine Sulfate (Patient Specific dosing)
11 Recruiting Hydroxyurea Adherence for Personal Best in Sickle Cell Treatment: HABIT
Condition: Sickle Cell Disease
Interventions: Behavioral: Community Health Worker (CHW);   Behavioral: Education
12 Recruiting Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure
Conditions: Sickle Cell Disease;   Thalassemia;   Stem Cell Transplantation;   Graft vs Host Disease
Interventions: Drug: Alemtuzumab;   Drug: Sirolimus;   Drug: Cyclophosphamide;   Drug: Pentostatin;   Drug: Radiotherapy
13 Recruiting Blood Flow and Pain Crises in People With Sickle Cell Disease
Condition: Sickle Cell Disease
Intervention:
14 Recruiting Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia
Conditions: Pulmonary Hypertension;   Sickle Cell Anemia;   Sickle Cell Disease
Intervention:
15 Recruiting Genetics and Pain Severity in Sickle Cell Disease
Conditions: Genotype;   Pain;   Sickle Cell Anemia;   Vaso-Occlusive Pain Crisis
Intervention:
16 Recruiting Carbon Monoxide Levels and Sickle Cell Disease Severity
Conditions: Sickle Cell Disease;   Sickle Cell Anemia;   Anemia, Sickle Cell
Intervention:
17 Recruiting Topical Sodium Nitrite for Chronic Leg Ulcers in Adult Patients With Blood Disorders
Conditions: Sickle Cell Anemia;   Sickle Cell Disease;   Chronic Hemolytic Disorders
Intervention: Drug: Sodium Nitrite Cream
18 Recruiting Microvessels and Heart Problems in Sickle Cell Disease
Condition: Sickle Cell Disease
Intervention:
19 Recruiting Decitabine for High-Risk Sickle Cell Disease
Conditions: Neutropenia;   Sickle Cell Disease
Intervention: Drug: Decitabine
20 Recruiting Assessment of Algorithm-Based Hydroxyurea Dosing on Fetal Hemoglobin Response, Acute Complications, and Organ Function in People With Sickle Cell Disease
Condition: Sickle Cell Disease
Intervention: Drug: Hydroxyurea

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Indicates status has not been verified in more than two years