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41 studies found for:    phenylbutyrate

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phenylbutyrate (41 records)
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Rank Status Study
1 Withdrawn Pilot Study of Safety and Efficacy of Sodium Phenylbutyrate in Spinocerebellar Ataxia Type 3
Condition: Spinocerebellar Ataxia Type 3
Interventions: Drug: Placebo;   Drug: Sodium Phenylbutyrate
2 Recruiting Clinical Trial of Phenylbutyrate and Vitamin D in Tuberculosis (TB)
Condition: Pulmonary Tuberculosis
Interventions: Drug: Active Sodium Phenylbutyrate and active cholecalciferol;   Drug: Placebo Sodium Phenylbutyrate plus active cholecalciferol;   Drug: Active Sodium Phenylbutyrate and placebo cholecalciferol;   Drug: Placebo Sodium Phenylbutyrate plus placebo cholecalciferol
3 Recruiting Phenylbutyrate Therapy for Maple Syrup Urine Disease
Condition: Maple Syrup Urine Disease
Interventions: Drug: Phenylbutyrate;   Drug: Placebo powder
4 Terminated Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer
Conditions: Mucinous Adenocarcinoma of the Colon;   Mucinous Adenocarcinoma of the Rectum;   Recurrent Colon Cancer;   Recurrent Rectal Cancer;   Signet Ring Adenocarcinoma of the Colon;   Signet Ring Adenocarcinoma of the Rectum;   Stage IVA Colon Cancer;   Stage IVA Rectal Cancer;   Stage IVB Colon Cancer;   Stage IVB Rectal Cancer
Interventions: Drug: fluorouracil;   Drug: sodium phenylbutyrate;   Drug: indomethacin;   Biological: recombinant interferon gamma
5 Completed Safety and Tolerability Study of Phenylbutyrate in Huntington's Disease (PHEND-HD)
Condition: Huntington's Disease
Intervention: Drug: sodium phenylbutyrate
6 Active, not recruiting Arginine and Buphenyl in Patients With Argininosuccinic Aciduria (ASA), a Urea Cycle Disorder
Conditions: Argininosuccinic Aciduria;   Amino Acid Metabolism, Inborn Errors;   Urea Cycle Disorders
Interventions: Drug: Sodium Phenylbutyrate (Buphenyl-TM);   Drug: Arginine
7 Completed A Study of Glyceryl Tri-(4-phenylbutyrate) (GT4P)
Condition: Healthy
Interventions: Drug: HPN-100;   Drug: Ammonul;   Drug: Buphenyl
8 Completed Mechanism of Fatty Acid-induced Impairment of Glucose-simulated Insulin Secretion - Effect of Buphenyl
Conditions: Diabetes;   Insulin Resistance
Interventions: Drug: sodium phenylbutyrate;   Drug: Placebo
9 Completed Safety Study of Oral Sodium Phenylbutyrate in Subjects With ALS (Amyotrophic Lateral Sclerosis)
Condition: Amyotrophic Lateral Sclerosis
Intervention: Drug: sodium phenylbutyrate
10 Completed Phenylbutyrate in Treating Patients With Refractory Solid Tumors or Lymphoma
Conditions: Lymphoma;   Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: chemotherapy;   Drug: oral sodium phenylbutyrate
11 Recruiting Immune Reconstitution in HIV Disease (IREHIV)
Condition: HIV Infection
Interventions: Drug: vitamin D (cholecalciferol) and PBA (sodium phenylbutyrate);   Drug: Placebo tablets
12 Recruiting Immune Reconstitution in Tuberculosis Disease
Condition: Pulmonary Tuberculosis (TB)
Interventions: Drug: vitamin D (cholecalciferol) and PBA (sodium phenylbutyrate);   Drug: Placebo tablets
13 Terminated
Has Results 		Phenylbutyrate/Genistein Duotherapy in Delta F508-Heterozygotes (for Cystic Fibrosis)
Condition: Cystic Fibrosis
Interventions: Drug: Sodium 4-Phenylbutyrate;   Drug: Genistein (Unconjugated Isoflavones 100);   Drug: Placebo
14 Completed Phenylbutyrate/Genistein Duotherapy in Delta F508-Homozygous(for Cystic Fibrosis)
Condition: Cystic Fibrosis
Interventions: Drug: Sodium 4-Phenylbutyrate (4PBA);   Drug: Unconjugated Isoflavones 100 (PTI G-4660, 87% Genistein);   Drug: Placebo
15 Terminated
Has Results 		Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Type I
Condition: Spinal Muscular Atrophy Type I
Intervention: Drug: sodium phenylbutyrate
16 Active, not recruiting Study to Evaluate Sodium Phenylbutyrate in Pre-symptomatic Infants With Spinal Muscular Atrophy
Condition: Spinal Muscular Atrophy
Intervention: Drug: Sodium phenylbutyrate (NaPB)
17 Terminated
Has Results 		Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Types II or III
Conditions: Spinal Muscular Atrophy Type II;   Spinal Muscular Atrophy Type III
Intervention: Drug: sodium phenylbutyrate
18 Completed Phenylbutyrate to Treat Children With Progressive or Recurrent Brain Tumors
Condition: Brain Tumor
Intervention: Drug: Phenylbutyrate
19 Unknown † Phenylbutyrate and Valganciclovir in Treating Patients With Relapsed or Refractory Epstein-Barr Virus-Positive Cancer
Conditions: Gastric Cancer;   Head and Neck Cancer;   Lymphoma;   Lymphoproliferative Disorder
Interventions: Drug: oral sodium phenylbutyrate;   Drug: valganciclovir;   Genetic: polymerase chain reaction;   Genetic: protein expression analysis;   Procedure: biopsy
20 Completed Azacitidine Plus Phenylbutyrate in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome
Conditions: Leukemia;   Myelodysplastic Syndromes;   Myelodysplastic/Myeloproliferative Diseases
Interventions: Drug: azacitidine;   Drug: sodium phenylbutyrate
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† Indicates status has not been verified in more than two years