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135 studies found for:    c1 inhibitor

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1 Completed A Study to Evaluate the Clinical Pharmacology and Safety of C1-esterase Inhibitor Administered by the Subcutaneous Route
Condition: Hereditary Angioedema Types I and II
Interventions: Biological: C1-esterase inhibitor - single intravenous dose;   Biological: C1-esterase inhibitor - subcutaneous low dose;   Biological: C1-esterase inhibitor - subcutaneous medium dose;   Biological: C1-esterase inhibitor - subcutaneous high dose
2 Recruiting Safety & Tolerability of Berinert® (C1 Inhibitor) Therapy to Prevent Rejection
Condition: Kidney Transplantation
Intervention: Biological: C1 Esterase Inhibitor
3 Recruiting Patient Registry Study of Berinert® in Normal Clinical Practice
Condition: Includes: Hereditary Angioedema
Intervention: Biological: Berinert® (C1 Esterase Inhibitor)
4 Completed Berinert P Study of Subcutaneous Versus Intravenous Administration
Condition: Hereditary Angioedema
Intervention: Drug: C1-Esterase Inhibitor
5 Completed A Study to Evaluate the Safety and Pharmacokinetics of Two Formulations of C1-esterase Inhibitor
Condition: Hereditary Angioedema Types I and II
Interventions: Biological: Berinert;   Biological: CSL830
6 Completed In Vivo Effects of C1-esterase Inhibitor on the Innate Immune Response During Human Endotoxemia
Conditions: Endotoxemia;   Inflammation;   Multi Organ Dysfunction Syndrome
Interventions: Drug: C1-esterase inhibitor;   Drug: Endotoxin administration
7 Recruiting Postmarketing Immunogenicity Study in HAE Subjects Treated With Berinert
Condition: Hereditary Angioedema Types I and II
Intervention: Biological: Berinert, lyophilisate for IV application containing 500 units (U) C1-INH to be reconstituted with 10 mL water for injection
8 Recruiting Effect of C1-esterase Inhibitor on Systemic Inflammation in Trauma Patients With a Femur or Pelvic Fracture
Conditions: Trauma;   Inflammation;   Sepsis;   Multiple Organ Dysfunction Syndrome
Interventions: Drug: C1-esterase inhibitor;   Other: Saline 0.9%
9 Active, not recruiting A Study to Evaluate the Safety and Effect of Escalating Doses of CINRYZE (C1 Inhibitor [Human])
Conditions: Hereditary Angioedema;   C1 Esterase Inhibitor Deficiency
Intervention: Biological: C1 inhibitor (human)
10 Completed
Has Results 		Human C1 Esterase Inhibitor (C1-INH) in Subjects With Acute Abdominal or Facial Hereditary Angioedema (HAE) Attacks
Condition: Hereditary Angioedema
Interventions: Biological: C1 Esterase Inhibitor;   Biological: Placebo
11 Completed
Has Results 		C1 Esterase Inhibitor in Hereditary Angioedema (HAE)(Extension Study)
Condition: Hereditary Angioedema
Intervention: Drug: C1 Esterase Inhibitor
12 Completed
Has Results 		Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema
Conditions: Hereditary Angioedema;   Angioneurotic Edema
Interventions: Drug: Recombinant Human C1 Inhibitor;   Drug: placebo
13 Not yet recruiting In Vivo Effects of C1-esterase Inhibitor on the Innate Immune Response During Human Endotoxemia - VECTOR II
Conditions: Innate Immune Response;   Endotoxemia;   Inflammation;   Sepsis
Interventions: Drug: C1-esterase inhibitor;   Drug: Endotoxin
14 Completed
Has Results 		Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema
Conditions: Hereditary Angioedema;   Angioneurotic Edema;   Genetic Disorders
Interventions: Drug: recombinant human C1 inhibitor;   Drug: Placebo
15 Recruiting C1 Inhibitor Registry in the Treatment of Hereditary Angioedema (HAE) Attacks
Condition: Hereditary Angioedema
Intervention: Drug: rhC1INH or pdC1INH
16 Completed Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema
Condition: Genetic Disorders
Intervention: Drug: i.v. recombinant human C1 inhibitor
17 Completed Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema
Condition: Genetic Disorders
Intervention: Drug: i.v. recombinant human C1 inhibitor
18 Completed
Has Results 		A Study of the Safety and Immunogenicity of Repeated rhC1INH Administration
Conditions: Genetic Disorders;   Hereditary Angioedema
Intervention: Drug: Recombinant Human C1 Inhibitor
19 Completed
Has Results 		Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks
Condition: Hereditary Angioedema
Intervention: Biological: C1 esterase inhibitor [human] (C1INH-nf)
20 Completed
Has Results 		C1 Esterase Inhibitor (C1INH-nf) for the Prevention of Acute Hereditary Angioedema (HAE) Attacks
Condition: Hereditary Angioedema
Interventions: Biological: C1 esterase inhibitor [human] (C1INH-nf);   Drug: Placebo (saline)
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† Indicates status has not been verified in more than two years