13 studies found for:    Thalassemias | Open Studies | NIH, U.S. Fed
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Rank Status Study
1 Recruiting Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure
Conditions: Sickle Cell Disease;   Thalassemia;   Stem Cell Transplantation;   Graft vs Host Disease
Interventions: Drug: Alemtuzumab;   Drug: Sirolimus;   Drug: Cyclophosphamide;   Drug: Pentostatin;   Drug: Radiotherapy
2 Recruiting Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Severe Congenital Anemias Including Sickle Cell Disease and Beta-Thalassemia
Conditions: Peripheral Blood Stem Cell Transplantation;   Anemia, Sickle Cell;   Graft-Versus-Host Disease;   Sirolimus (Rapamune );   Alemtuzumab (Campath )
Interventions: Procedure: PBMC Transplant;   Drug: Alemtuzumab (Campath );   Drug: Sirolimus (Rapamune );   Drug: Cyclophosphamide (Cytoxan );   Procedure: Low Dose Irradiation
3 Unknown  Evaluating the Safety and Effectiveness of Mozobil Mobilization in Adults With Beta-Thalassemia Major
Condition: Beta-Thalassemia
Intervention: Drug: Mozobil
4 Recruiting Retroviral Vector Mediated Globin Gene Transfer to Correct Sickle Cell Anemia or Thalassemia
Conditions: Sickle Cell Anemia;   Thalassemia
Intervention: Genetic: Gene Therapy
5 Recruiting Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias
Conditions: Congenital Hemolytic Anemia;   Diamond-Blackfan Anemia
Interventions: Procedure: Radiotherapy;   Drug: Alemtuzumab (Campath );   Drug: Sirolimus (Rapamune )
6 Recruiting Effects of Transfusion of Older Red Blood Cells on Patients With Hemoglobinopathies
Conditions: Sickle Cell Disease;   Thalassemia
Intervention: Biological: Transfusion
7 Recruiting Treatment of Sickle Cell Anemia With Stem Cell Transplant
Conditions: Sickle Cell Anemia;   Sickle Cell-hemoglobin C Disease;   Sickle Cell-β0-thalassemia
Interventions: Drug: Fludarabine;   Drug: Cytarabine;   Device: Cellular Infusions;   Radiation: Total Body Irradiation;   Drug: Cyclophosphamide;   Drug: Bortezomib;   Drug: Rituximab;   Procedure: Plasmapheresis
8 Recruiting Topical Sodium Nitrite for Chronic Leg Ulcers in Adult Patients With Blood Disorders
Conditions: Sickle Cell Anemia;   Sickle Cell Disease;   Chronic Hemolytic Disorders
Intervention: Drug: Sodium Nitrite Cream
9 Recruiting Natural History of Sickle Cell Disease and Other Hemolytic Disorders
Conditions: Hemoglobin SC Disease;   Hematologic Diseases;   Sickle Cell Anemia;   Hemolytic Anemia
Intervention:
10 Recruiting Massive Iron Deposit Assessment
Conditions: Iron Overload;   Excessive Body Iron Burden
Interventions: Device: R2*-UTE;   Device: R2*-GRE;   Procedure: Liver biopsy
11 Unknown  Phase II Randomized Trial of Arginine Butyrate Plus Standard Local Therapy in Patients With Refractory Sickle Cell Ulcers
Conditions: Skin Ulcers;   Sickle Cell Anemia
Intervention: Drug: arginine butyrate
12 Recruiting Treosulfan and Fludarabine Phosphate Before Donor Stem Cell Transplant in Treating Patients With Nonmalignant Inherited Disorders
Condition: Nonmalignant Neoplasm
Interventions: Drug: treosulfan;   Drug: fludarabine phosphate;   Biological: anti-thymocyte globulin;   Radiation: total-body irradiation;   Procedure: allogeneic bone marrow transplantation;   Procedure: peripheral blood stem cell transplantation;   Procedure: umbilical cord blood transplantation;   Drug: tacrolimus;   Drug: methotrexate;   Drug: cyclosporine;   Drug: mycophenolate mofetil;   Other: laboratory biomarker analysis
13 Recruiting Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia
Conditions: Pulmonary Hypertension;   Sickle Cell Anemia;   Sickle Cell Disease
Intervention:

Indicates status has not been verified in more than two years