195 studies found for:    Primary Lateral Sclerosis
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Primary Lateral Sclerosis (195 records)
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Rank Status Study
1 Completed Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis
Conditions: Primary Lateral Sclerosis;   Hereditary Spastic Paraplegia;   Amyotrophic Lateral Sclerosis
Intervention:
2 Recruiting Screening and Natural History: Primary Lateral Sclerosis and Related Disorders
Conditions: Motor Nueron Disease;   Nervous System Diseases;   Muscle Spasticity;   Diffusion Tensor Imaging;   Disease Progression;   Evoked Potentials, Motor/Physiology
Intervention:
3 Completed Brain Function in Primary Lateral Sclerosis
Condition: Motor Neuron Disease
Intervention:
4 Completed Brain Function in Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis
Condition: Cerebral Cortex Dysfunction
Intervention:
5 Active, not recruiting Oxidative Stress in Motor Neuron Disease: COSMOS Add-On Study
Conditions: Motor Neuron Disease;   Primary Lateral Sclerosis
Intervention:
6 Recruiting Genetics of ALS: Identification of Genes With Roles in Familial and Sporadic Amyotrophic Lateral Sclerosis (ALS) and Amyotrophic Lateral Sclerosis (ALS) With Frontotemporal Dementia
Conditions: Amyotrophic Lateral Sclerosis;   Familial Amyotrophic Lateral Sclerosis;   Amyotrophic Lateral Sclerosis With Frontotemporal Dementia;   Lou Gehrig's Disease;   Motor Neuron Disease;   Primary Lateral Sclerosis
Intervention: Other: Genetic study of ALS families
7 Completed Collection of Blood Samples for DNA in Motor Neuron Disease
Condition: Motor Neuron Diseases
Intervention:
8 Completed Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease
Conditions: Motor Neuron Disease;   Amyotrophic Lateral Sclerosis;   Primary Lateral Sclerosis;   Progressive Muscular Atrophy
Intervention: Biological: Levetiracetam
9 Active, not recruiting Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS)
Conditions: Amyotrophic Lateral Sclerosis;   Lou Gehrig's Disease;   Primary Lateral Sclerosis;   Nervous System Diseases;   Hereditary Spastic Paraparesis
Intervention: Other: No intervention
10 Completed Physiologic Studies of Spasticity
Conditions: Muscle Spasticity;   Healthy
Intervention:
11 Recruiting Toxin Treatment for Amyotrophic Lateral Sclerosis (ALS) Related Sialorrhea
Conditions: Sialorrhea;   Amyotrophic Lateral Sclerosis
Interventions: Drug: Botox injection;   Drug: Placebo injection
12 Completed A Study of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)
Condition: Amyotrophic Lateral Sclerosis
Interventions: Drug: Placebo;   Drug: 250 mg CK-2017357;   Drug: 500 mg CK-2017357
13 Active, not recruiting Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral Sclerosis
Conditions: Amyotrophic Lateral Sclerosis 1;   Acquired Amyotrophic Lateral Sclerosis;   Amyotrophic Lateral Sclerosis
Intervention: Drug: Arimoclomol
14 Completed Safety and Efficacy of TRO19622 as add-on Therapy to Riluzole Versus Placebo in Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS)
Condition: Amyotrophic Lateral Sclerosis
Interventions: Drug: Olesoxime;   Drug: Placebo Comparator
15 Completed Growth Hormone in Amyotrophic Lateral Sclerosis
Condition: Amyotrophic Lateral Sclerosis
Interventions: Drug: Growth Hormone (Somatropin);   Drug: Placebo
16 Completed Open-Label, Safety and Tolerability Extension Study of KNS-760704 in Amyotrophic Lateral Sclerosis (ALS) (CL211)
Condition: Amyotrophic Lateral Sclerosis
Intervention: Drug: KNS-760704
17 Recruiting Study of miRNA Expression Pattern as Diagnostic and Prognostic Biomarker in Amyotrophic Lateral Sclerosis
Conditions: Amyotrophic Lateral Sclerosis;   ALS
Interventions: Other: Clinical evaluation;   Procedure: Muscular biopsy;   Procedure: Lumbar puncture;   Procedure: Blood sampling;   Other: Neurological assessments;   Procedure: Neuro-muscular biopsy and lumbar puncture;   Procedure: Blood sample;   Device: Cervical spinal cord and brain MRI
18 Active, not recruiting Human Spinal Cord Derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral Sclerosis
Condition: Amyotrophic Lateral Sclerosis
Intervention: Device: surgical implantation
19 Active, not recruiting Trial of Safety and Efficacy of Rasagiline in Patients With Amyotrophic Lateral Sclerosis (ALS)
Condition: Amyotrophic Lateral Sclerosis (ALS)
Intervention: Drug: rasagiline
20 Terminated Pilot-Study of Thalidomide in Amyotrophic Lateral Sclerosis (ALS)
Condition: Amyotrophic Lateral Sclerosis (ALS)
Intervention: Drug: Thalidomide (drug)

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Indicates status has not been verified in more than two years