247 studies found for:    Neurotoxicity
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Rank Status Study
21 Terminated Amifostine in Treating Women With Ovarian, Peritoneal, Cervical, Fallopian Tube, Uterine, or Endometrial Cancer
Conditions: Cervical Cancer;   Endometrial Cancer;   Fallopian Tube Cancer;   Neurotoxicity;   Ovarian Cancer;   Primary Peritoneal Cavity Cancer;   Sarcoma
Interventions: Drug: amifostine trihydrate;   Drug: cisplatin;   Drug: paclitaxel
22 Unknown  Combination Chemotherapy in Treating Younger Patients With Hodgkin Lymphoma
Conditions: Lymphoma;   Neurotoxicity
Interventions: Drug: cyclophosphamide;   Drug: doxorubicin hydrochloride;   Drug: etoposide;   Drug: prednisolone;   Drug: procarbazine hydrochloride;   Drug: vincristine sulfate;   Radiation: radiation therapy
23 Completed Amifostine in Treating Peripheral Neuropathy Caused by Paclitaxel in Patients With Solid Tumors
Conditions: Breast Cancer;   Lung Cancer;   Neurotoxicity;   Ovarian Cancer;   Prostate Cancer;   Unspecified Adult Solid Tumor, Protocol Specific
Intervention: Drug: Amifostine
24 Completed S0715: Acetyl-L-Carnitine in Preventing Neuropathy in Women With Stage I, Stage II, or Stage IIIA Breast Cancer Undergoing Chemotherapy
Conditions: Breast Cancer;   Chemotherapeutic Agent Toxicity;   Fatigue;   Neuropathy;   Neurotoxicity
Interventions: Dietary Supplement: acetyl-L-carnitine hydrochloride;   Other: placebo
25 Enrolling by invitation Prospective Observational Pilot-study for the Evaluation of the Nephro- an Neurotoxicity in the Anti-infectious Therapy With Inhalative Colistin Therapy for Patients With Ventilator-associated Pneumonia (VAP)
Condition: Infection Resistant to Multiple Drugs
Intervention: Other: TDM, Monitoring of Neuro-and Nephropathology
26 Withdrawn Pilot Study of MGd + High-dose MTX-Based Chemoimmunotherapy + RT for Newly Dx PCNSL
Conditions: Brain and Central Nervous System Tumors;   Lymphoma;   Neurotoxicity
Interventions: Biological: Rituximab;   Drug: Cytarabine;   Drug: Methotrexate;   Drug: Motexafin gadolinium;   Drug: Procarbazine hydrochloride;   Drug: Vincristine sulfate;   Radiation: Radiation therapy
27 Active, not recruiting Brain Function in Young Patients Receiving Methotrexate for Acute Lymphoblastic Leukemia
Conditions: B-cell Childhood Acute Lymphoblastic Leukemia;   Cognitive/Functional Effects;   Long-term Effects Secondary to Cancer Therapy in Children;   Neurotoxicity;   Psychosocial Effects of Cancer and Its Treatment;   T-cell Childhood Acute Lymphoblastic Leukemia;   Untreated Childhood Acute Lymphoblastic Leukemia
Interventions: Procedure: cognitive assessment;   Procedure: psychosocial assessment and care;   Procedure: diffusion tensor imaging;   Other: laboratory biomarker analysis;   Other: pharmacological study
28 Not yet recruiting Advanced Neuroimaging Evaluation of the Central Nervous System Biological Changes Associated With Efavirenz Therapy Switch to an Raltegravir-based Regimen
Conditions: HIV;   HIV-associated Neurocognitive Disorder;   Neurotoxicity
Intervention: Drug: switch efavirenz (EFV) to raltegravir (RAL)
29 Withdrawn A Trial of Glutamine to Prevent Oxaliplatin Neurotoxicity and a Pharmacokinetic Analysis of Oxaliplatin
Conditions: Colorectal Carcinoma;   Neoplasms, Colorectal;   Colorectal Cancer;   Colorectal Tumors;   Metastasis
Intervention: Dietary Supplement: Glutamine
30 Unknown  N-AcetylCysteine vs. Placebo to Prevent Neurotoxicity Induced by Platinum Containing Chemotherapy
Conditions: Carcinoma, Non-Small-Cell Lung;   Carcinoma, Small Cell Lung;   Mesothelioma
Interventions: Drug: N-Acetylcysteine;   Drug: Placebo
31 Active, not recruiting Effects of Chemotherapy on the Brain in Women With Newly Diagnosed Early-Stage Breast Cancer
Conditions: Breast Cancer;   Chemotherapeutic Agent Toxicity;   Cognitive/Functional Effects;   Fatigue;   Long-term Effects Secondary to Cancer Therapy in Adults;   Neurotoxicity;   Psychosocial Effects of Cancer and Its Treatment
Interventions: Biological: trastuzumab;   Drug: aromatase inhibition therapy;   Drug: carboplatin;   Drug: cyclophosphamide;   Drug: docetaxel;   Drug: doxorubicin hydrochloride;   Other: metabolic assessment;   Other: questionnaire administration;   Other: study of socioeconomic and demographic variables;   Procedure: cognitive assessment;   Procedure: positron emission tomography;   Radiation: fludeoxyglucose F 18
32 Completed Amifostine in Treating Peripheral Neuropathy in Patients Who Have Received Chemotherapy for Cancer
Conditions: Gestational Trophoblastic Tumor;   Neurotoxicity;   Peripheral Neuropathy;   Unspecified Adult Solid Tumor, Protocol Specific
Intervention: Drug: amifostine trihydrate
33 Completed Nerve Changes in Patients Who Are Undergoing Chemotherapy or Biological Therapy for Cancer
Conditions: Neurotoxicity;   Unspecified Adult Solid Tumor, Protocol Specific
Intervention: Procedure: management of therapy complications
34 Completed Glutamine in Treating Neuropathy Caused by Vincristine in Young Patients With Lymphoma, Leukemia, or Solid Tumors
Conditions: Kidney Cancer;   Leukemia;   Lymphoma;   Neurotoxicity;   Peripheral Neuropathy;   Sarcoma
Interventions: Drug: Glutamine;   Other: Placebo
35 Active, not recruiting
Has Results
Donepezil in Treating Young Patients With Primary Brain Tumors Previously Treated With Radiation Therapy to the Brain
Conditions: Brain and Central Nervous System Tumors;   Cognitive/Functional Effects;   Long-term Effects Secondary to Cancer Therapy in Children;   Neurotoxicity;   Psychosocial Effects of Cancer and Its Treatment;   Radiation Toxicity
Intervention: Drug: Donepezil
36 Unknown  Pelvic Radiation Therapy or Vaginal Implant Radiation Therapy, Paclitaxel, and Carboplatin in Treating Patients With High-Risk Stage I or Stage II Endometrial Cancer
Conditions: Endometrial Cancer;   Fatigue;   Neurotoxicity
Interventions: Drug: carboplatin;   Drug: paclitaxel;   Radiation: brachytherapy;   Radiation: intensity-modulated radiation therapy;   Radiation: radiation therapy
37 Completed Carboxypeptidase-G2 in Treating Nervous System Toxic Effects in Patients Given an Overdose of Intrathecal Methotrexate
Conditions: Neurotoxicity;   Unspecified Adult Solid Tumor, Protocol Specific;   Unspecified Childhood Solid Tumor, Protocol Specific
Intervention: Drug: glucarpidase
38 Active, not recruiting L-Carnitine L-Tartrate in Preventing Peripheral Neuropathy Caused By Chemotherapy in Women With Metastatic Breast Cancer
Conditions: Breast Cancer;   Chemotherapeutic Agent Toxicity;   Neurotoxicity
Interventions: Drug: L-carnitine L-tartrate;   Other: placebo
39 Completed Gabapentin in Treating Peripheral Neuropathy in Cancer Patients Undergoing Chemotherapy
Conditions: Neurotoxicity;   Pain
Interventions: Drug: gabapentin;   Procedure: quality-of-life assessment
40 Withdrawn Acetyl-L-Carnitine Hydrochloride in Preventing Peripheral Neuropathy in Patients With Recurrent Ovarian Epithelial Cancer, Primary Peritoneal Cavity Cancer, or Fallopian Tube Cancer Undergoing Chemotherapy
Conditions: Fallopian Tube Cancer;   Fatigue;   Neuropathy;   Neurotoxicity;   Ovarian Cancer;   Pain;   Primary Peritoneal Cavity Cancer
Interventions: Dietary Supplement: acetyl-L-carnitine hydrochloride;   Drug: carboplatin;   Drug: cisplatin;   Drug: paclitaxel;   Other: placebo

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Indicates status has not been verified in more than two years