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64 studies found for:    Alpha-1 Antitrypsin Deficiency
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Rank Status Study
1 Recruiting Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (AATD)
Conditions: Liver Fibrosis;   Alpha-1 Antitrypsin Deficiency;   AAT Deficiency;   AATD
Interventions: Device: Abdominal ultrasound;   Procedure: History and physical;   Procedure: Intravenous catheter;   Procedure: Blood draw;   Other: Liver questionnaire;   Procedure: Liver Biopsy;   Drug: Midazolam;   Drug: Fentanyl;   Drug: Lidocaine;   Drug: Acetaminophen;   Drug: Lorazepam;   Drug: Oxycodone/Acetaminophen;   Drug: Ondansetron
2 Completed
Has Results
Safety and Pharmacokinetics of Alpha-1 Proteinase Inhibitor in Subjects With Alpha1-Antitrypsin Deficiency
Conditions: Emphysema;   Alpha 1-antitrypsin Deficiency (AATD)
Interventions: Biological: Prolastin-C, 60 mg/kg;   Biological: Prolastin-C, 120 mg/kg
3 Recruiting Alpha-1 Antitrypsin Deficiency Adult Liver Study
Condition: Alpha-1 Antitrypsin Deficiency
Intervention: Procedure: Liver Biopsy
4 Recruiting Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency
Conditions: Alpha-1-antitrypsin Deficiency;   Liver Cirrhosis
Interventions: Drug: Drug-Carbamazepine (Tegretol XR);   Drug: Carbamazepine (Tegretol XR) Placebo
5 Unknown  Endoscopic Lung Volume Reduction in Patients With Advanced Emphysema Due to alpha1 Antitrypsin Deficiency
Condition: Hereditary Emphysema (Alpha 1-antitrypsin Deficiency)
Intervention: Device: Implantation of intrabronchial valves (IBV) (Spiration IBV)
6 Completed Prevalence of Alpha-1 Antitrypsin Deficiency in Chronic Obstructive Pulmonary Disease (COPD)
Conditions: Alpha-1 Antitrypsin Deficiency;   Chronic Obstructive Pulmonary Disease
Intervention:
7 Completed
Has Results
Comparison of Pharmacokinetic, Safety, Tolerability of Alpha-1 MP and Prolastin In Alpha1-antitrypsin Deficient Adults
Condition: Alpha 1-Antitrypsin Deficiency
Interventions: Drug: Alpha-1 MP;   Drug: alpha-1 proteinase inhibitor (human)
8 Active, not recruiting
Has Results
Safety & Efficacy Study of rAAV1-CB-hAAT for Alpha-1 Antitrypsin Deficiency
Condition: Alpha-1 Antitrypsin Deficiency
Intervention: Drug: rAAV1-CB-hAAT
9 Completed Effects of Exercise Training in Chronic Obstructive Pulmonary Disease Versus Alpha-1-Antitrypsin-deficiency-patients
Conditions: Chronic Obstructive Pulmonary Disease;   Alpha-1-antitrypsin-deficiency
Intervention: Procedure: exercise training
10 Not yet recruiting Safety Study of Gene Transfer Vector to Treat alpha1-antitrypsin Deficiency
Condition: alpha1-antitrypsin Deficiency
Intervention: Genetic: AAVrh.10halpha1AT
11 Recruiting Genomic Research in Alpha-1 Antitrypsin Deficiency
Conditions: Alpha 1 Antitrypsin Deficiency;   AATD
Intervention:
12 Completed
Has Results
Efficacy and Safety Study of Augmentation Therapy With ARALAST Fraction IV-1 (Human Alpha 1 - Proteinase Inhibitor)
Condition: Alpha 1-Antitrypsin Deficiency
Intervention: Biological: Alpha1-Proteinase Inhibitor
13 Completed
Has Results
Pharmacokinetic Study of ARALAST (Human Alpha1- PI)
Condition: Alpha 1-Antitrypsin Deficiency
Interventions: Biological: Dose of 60 mg/kg Fraction IV-1 Alpha1-Proteinase Inhibitor;   Biological: Dose of 60 mg/kg alpha1-proteinase inhibitor
14 Completed The Use of High Resolution Chest Computed Tomography in Alpha-1 Antitrypsin Deficiency
Condition: Alpha-1 Antitrypsin Deficiency
Intervention:
15 Completed Extension Study of Zemaira® i.v. Administration in Subjects With Emphysema Due to alpha1-proteinase Inhibitor Deficiency.
Conditions: Emphysema;   Alpha 1-proteinase Inhibitor Deficiency
Intervention: Biological: Alpha1- proteinase inhibitor [human]
16 Completed Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor (API) Deficiency
Conditions: Alpha1-proteinase Inhibitor Deficiency;   Emphysema
Interventions: Biological: Alpha1-proteinase inhibitor;   Other: Placebo
17 Completed Safety Study of an Aerosolized, Recombinant Alpha 1-Antitrypsin in Subjects With Alpha 1-Antitrypsin Deficiency
Condition: Alpha 1-Antitrypsin Deficiency
Intervention: Drug: Aerosolized, Recombinant Alpha 1-Antitrypsin
18 Recruiting Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD)
Condition: Pulmonary Emphysema in Alpha-1 PI Deficiency
Interventions: Biological: Alpha1-proteinase inhibitor (human), modified process (Alpha-1 MP);   Other: 0.9% Sodium Chloride for Injection, USP
19 Recruiting Lung Volume Reduction Coils for Emphysema in Alpha-1 Antitrypsin Deficiency
Conditions: Alpha-1-Antitrypsin Deficiency;   Chronic Obstructive Lung Disease;   Emphysema
Intervention: Device: Lung Volume Reduction Coil (PneumrX Inc.)
20 Completed
Has Results
Alpha-1-Antitrypsin (AAT) To Treat Emphysema In AAT-Deficient Patients (EXACTLE)
Condition: Alpha 1-Antitrypsin Deficiency
Interventions: Drug: Alpha1-Proteinase Inhibitor (Human);   Drug: Albumin (Human) 20%, United States Pharmacopeia (USP)

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