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5139 studies found for:    "gene therapy" OR "gene transfer" OR "virus delivery" | Closed Studies

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Rank Status Study
1 Completed Gene Transfer Therapy for Treating Children and Adults With Limb Girdle Muscular Dystrophy Type 2D (LGMD2D)
Condition: Muscular Dystrophies
Interventions: Genetic: rAAV1.tMCK.human-alpha-sarcoglycan- First cohort;   Genetic: Genetic: rAAV1.tMCK.human-alpha-sarcoglycan- Second cohort
2 Active, not recruiting Follow-up of Breast Cancer and Multiple Myeloma Patients Previously Enrolled in NIH Gene Therapy Studies
Condition: Gene Transfer
Intervention:
3 Completed ADA Gene Transfer Into Hematopoietic Stem/Progenitor Cells for the Treatment of ADA-SCID
Condition: Immunologic Deficiency Syndromes
Intervention: Genetic: Gene transduced CD34+ cells
4 Terminated Gene Transfer for HIV Using Autologous T Cells
Condition: HIV-1 Infection
Intervention: Genetic: pHIV7-shI-TAR-CCR5RZ treated CD4 cells
5 Active, not recruiting Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency
Condition: Alpha 1-Antitrypsin Deficiency
Intervention: Genetic: rAAV2-CB-hAAT Gene Vector
6 Active, not recruiting Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency
Condition: Alpha 1-Antitrypsin Deficiency
Intervention: Biological: rAAV1-CB-hAAT
7 Terminated Study of AAV-GAD Gene Transfer Into the Subthalamic Nucleus for Parkinson's Disease
Condition: Parkinson's Disease
Intervention: Genetic: Bilateral surgical infusion of AAV-GAD into the subthalamic nucleus
8 Completed Bone Marrow Cell Gene Transfer in Individuals With Fanconi Anemia
Condition: Fanconi Anemia
Intervention: Genetic: Retrovirus Construct
9 Withdrawn Stem Cell Mobilization and VEGF Gene Transfer for Heart Failure
Condition: Ischemic Congestive Heart Failure (CHF)
Intervention: Genetic: Vascular Endothelial Growth Factor (VEGF1)
10 Completed Safety Study of hMaxi-K Gene Transfer to Treat Overactive Bladder Syndrome and Detrusor Overactivity
Condition: Overactive Bladder
Interventions: Genetic: hMaxi-K;   Drug: hMaxi-K;   Other: Placebo
11 Completed Phase I Pilot Study of Gene Therapy for Cystic Fibrosis Using Cationic Liposome Mediated Gene Transfer
Condition: Cystic Fibrosis
Intervention: Genetic: pGT-1 gene lipid complex
12 Unknown † Phase I Study of Adenoviral Vector Mediated Gene Transfer for Ornithine Transcarbamylase in Adults With Partial Ornithine Transcarbamylase Deficiency
Condition: Ornithine Transcarbamylase Deficiency Disease
Intervention: Genetic: Adenoviral Vector-Mediated Gene Transfer
13 Enrolling by invitation Follistatin Gene Transfer to Patients With Becker Muscular Dystrophy and Sporadic Inclusion Body Myositis
Conditions: Becker Muscular Dystrophy;   Sporadic Inclusion Body Myositis
Intervention: Biological: rAAV1.CMV.huFollistatin344
14 Completed Gene Therapy for ADA-SCID
Condition: Severe Combined Immunodeficiency Syndrome
Intervention: Genetic: gene transduced PBL and/or gene transduced HSC
15 Terminated Gene Therapy and Chemotherapy in Treating Patients With Advanced Solid Tumors or Non-Hodgkin's Lymphoma
Conditions: Brain and Central Nervous System Tumors;   Lymphoma;   Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Biological: filgrastim;   Biological: sargramostim;   Biological: therapeutic autologous lymphocytes;   Drug: O6-benzylguanine;   Drug: carmustine;   Drug: temozolomide;   Procedure: in vitro-treated peripheral blood stem cell transplantation
16 Terminated Safety and Efficacy of Targeted Gene Transfer in Colorectal Cancer Metastatic to Liver
Condition: Colorectal Neoplasms
Intervention: Genetic: Mx-dnG1 Retroviral Vector
17 Active, not recruiting Safety Study of a Gene Transfer Vector for Children With Late Infantile Neuronal Ceroid Lipofuscinosis
Conditions: Batten Disease;   Late Infantile Neuronal Lipofuscinosis
Interventions: Genetic: AAV2CUhCLN2;   Procedure: Neurological surgery
18 Completed Stem Cell Gene Therapy to Treat X-Linked Severe Combined Immunodeficiency (XSCID)
Condition: Severe Combined Immunodeficiency
Intervention: Drug: Gene-Transduced Autologous CD34+ Stem Cells
19 Terminated Evaluation of Safety of Rexin-G Gene Transfer for Advanced Pancreatic Cancer
Condition: Pancreatic Cancer
Interventions: Genetic: Rexin-G Dose 1;   Genetic: Rexin-G Dose 2;   Genetic: Rexin-G Dose 3;   Genetic: Rexin-G Dose 4
20 Completed VEGF Gene Transfer for Diabetic Neuropathy
Condition: Diabetic Neuropathy
Intervention: Biological: VEGF
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† Indicates status has not been verified in more than two years