1091 studies found for:    Open Studies | "Antineoplastic Agents, Alkylating"
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Rank Status Study
1 Recruiting Randomized Study of Combination Chemotherapy With or Without Focused Microwave Thermotherapy Before Surgery in Treating Women With Large Breast Cancer Tumors
Condition: Breast Cancer
Interventions: Device: Focused Microwave Thermotherapy;   Drug: Chemotherapy (control)
2 Recruiting MINIALO-VELCADE2005: A Study of Bortezomib (Velcade) Treated Multiple Myeloma Patients Pre and Post Allogeneic Haematopoietic Progenitor Cell Transplant With no Myeloablative Conditioning
Condition: Multiple Myeloma
Interventions: Drug: Bortezomib;   Drug: dexamethasone;   Drug: Fludarabine;   Drug: Melphalan
3 Recruiting Combined Haploidentical-Cord Blood Transplantation for Adults and Children
Conditions: Leukemia;   Myelodysplastic Syndrome;   Multiple Myeloma;   Lymphoma
Interventions: Drug: Fludarabine-Melphalan & Rabbit antithymocyte globulin (r-ATG);   Procedure: Stem Cell Transplant;   Procedure: Stem Cells Collections;   Drug: Fludarabine, Thiotepa, Antithymocyte globulin (ATG), and Total Body Irradiation (TBI);   Drug: Fludarabine, Busulfan, and ATG
4 Recruiting Stem Cell Collection With Ofatumumab
Condition: Lymphoma
Interventions: Drug: Ofatumumab;   Drug: Ifosfamide;   Drug: Etoposide;   Drug: Mesna;   Drug: G-CSF;   Procedure: Stem Cell Collection
5 Recruiting Scleroderma Treatment With Autologous Transplant (STAT) Study
Condition: Systemic Scleroderma
Interventions: Procedure: peripheral blood stem cell transplantation;   Drug: cyclophosphamide;   Biological: anti-thymocyte globulin;   Other: questionnaire administration;   Other: laboratory biomarker analysis;   Other: quality-of-life assessment;   Biological: filgrastim;   Procedure: autologous hematopoietic stem cell transplantation;   Drug: mycophenolate mofetil;   Drug: plerixafor
6 Unknown  HLA-haploidentical Hematopoietic Stem Cell Transplantation for Children and Adolescents With Acute Leukemia, Myelodysplastic Syndrome and Solid Tumors
Conditions: Acute Leukemia;   Myelodysplastic Syndrome;   Solid Tumors
Interventions: Biological: anti-thymocyte globulin;   Biological: filgrastim;   Radiation: Total body irradiation;   Drug: Fludarabine;   Drug: cyclophosphamide;   Drug: Tacrolimus;   Drug: Mycophenolate mofetil;   Drug: Rituximab
7 Recruiting Cisplatin vs. Doxorubicin/Cyclophosphamide in BrCa
Condition: Breast Cancer
Interventions: Drug: Cisplatin;   Drug: Cyclophosphamide;   Drug: Doxorubicin
8 Recruiting Anti-Angiogenic Therapy Post Transplant (ASCR) for Relapsed and Refractory Pediatric Solid Tumors
Conditions: Glioma;   Neuroectodermal Tumors, Primitive;   Wilms Tumor;   Rhabdomyosarcoma;   Sarcoma, Ewing;   Osteosarcoma;   Retinoblastoma
Interventions: Drug: Metronomic Cyclophosphamide;   Drug: Thalidomide
9 Recruiting Phase II Trial of Chemotherapy With Temodar With Topotecan for CNS Metastasis of Solid Tumors
Conditions: Central Nervous System (CNS) Metastases;   Brain Metastases
Interventions: Drug: Topotecan;   Drug: Temozolomide
10 Not yet recruiting Treosulfan Pharmacokinetics in Children Undergoing Allogeneic HSCT
Condition: Allogeneic Haematopoietic Stem Cell Transplantation
Intervention: Drug: Treosulfan
11 Recruiting CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant
Conditions: Chronic Myeloid Leukemia (CML);   Acute Myelogenous Leukemia (AML);;   Myelodysplastic Syndrome (MDS);;   Juvenile Myelomonocytic Leukemia (JMML);;   Acute Lymphoblastic Leukemia (ALL);;   Lymphoma (Hodgkin's and Non-Hodgkin's)
Interventions: Device: CliniMACS CD34+ Reagent System;   Drug: Thiotepa;   Drug: Cyclophosphamide;   Drug: Alemtuzumab;   Drug: Tacrolimus;   Drug: Melphalan;   Drug: Busulfan;   Drug: Fludarabine
12 Unknown  An All-Oral Combination of Capecitabine and Cyclophosphamide in Patients With Metastatic Breast Cancer (MBC)
Condition: Breast Cancer
Intervention: Drug: capecitabine and cyclophosphamide
13 Recruiting Immune Tolerance Induction Study
Conditions: Pompe Disease;   Glycogen Storage Disease Type II (GSD-II);   Glycogenesis 2 Acid Maltase Deficiency
Intervention: Biological: Myozyme (alglucosidase alfa)
14 Recruiting Umbilical Cord Blood Transplant for Children With Myeloid Hematological Malignancies
Condition: Myeloid Hematological Malignancies
Interventions: Drug: Busulfan;   Drug: Cyclophosphamide;   Drug: Fludarabine;   Procedure: Cord Blood Stem Cell Infusion
15 Recruiting A Two-Step Approach to Bone Marrow Transplant Using Cells From One or Two Partially-Matched Relatives
Condition: Hematologic Malignancy
Interventions: Radiation: Total Body Irradiation (TBI);   Biological: Donor Lymphocyte Infusion (DLI);   Drug: Cyclophosphamide;   Biological: Stem Cell Infusion
16 Recruiting A Research Study of Bone Marrow Transplantation From Unrelated or Partially Matched Related Donors
Condition: Hematological Malignancies
Interventions: Radiation: Total Body Irradiation;   Drug: Cyclophosphamide;   Drug: Tacrolimus;   Drug: Mycophenolate mofetil;   Drug: Fludarabine;   Drug: Thiotepa;   Genetic: Hematopoietic stem cell transplantation
17 Recruiting Allogeneic Hematopoietic Stem Cell Transplantation for Multiple Myeloma
Condition: Multiple Myeloma
Intervention: Drug: Fludarabine monophosphate, melphalan, Bortezomib
18 Recruiting A Phase I Dose Escalation Study of BKM120 With Radiation Therapy and Temozolomide in Patients With Newly Diagnosed Glioblastoma
Condition: Glioblastoma
Interventions: Drug: BKM120 + temozolomide;   Drug: BKM120 +temozolomide with/without radiotherapy
19 Recruiting Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas
Conditions: Childhood Mixed Glioma;   Untreated Childhood Anaplastic Astrocytoma;   Untreated Childhood Brain Stem Glioma;   Untreated Childhood Fibrillary Astrocytoma;   Untreated Childhood Giant Cell Glioblastoma;   Untreated Childhood Glioblastoma;   Untreated Childhood Gliosarcoma
Interventions: Drug: veliparib;   Drug: temozolomide;   Radiation: 3-dimensional conformal radiation therapy;   Radiation: intensity-modulated radiation therapy;   Other: pharmacological study;   Other: laboratory biomarker analysis
20 Recruiting Phase I and Consecutive Phase II, Two-arm, Randomized Multi-center Trial in Patients With Advanced Melanoma
Condition: Advanced Melanoma
Intervention: Drug: dacarbazine (DTIC), Trofosfamide, Etoricoxib, Pioglitazone, Temsirolimus

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