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118 studies found for:    Open Studies | "Laryngeal Diseases"

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Rank Status Study
21 Recruiting Erlotinib Hydrochloride and Surgery in Treating Patients With Head and Neck Cancer That Can Be Removed By Surgery
Conditions: Squamous Cell Carcinoma of the Skin;   Stage I Squamous Cell Carcinoma of the Hypopharynx;   Stage I Squamous Cell Carcinoma of the Larynx;   Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity;   Stage I Squamous Cell Carcinoma of the Oropharynx;   Stage I Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity;   Stage I Verrucous Carcinoma of the Larynx;   Stage I Verrucous Carcinoma of the Oral Cavity;   Stage II Squamous Cell Carcinoma of the Hypopharynx;   Stage II Squamous Cell Carcinoma of the Larynx;   Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity;   Stage II Squamous Cell Carcinoma of the Oropharynx;   Stage II Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity;   Stage II Verrucous Carcinoma of the Oral Cavity
Interventions: Drug: erlotinib hydrochloride;   Procedure: therapeutic conventional surgery
22 Recruiting Docetaxel, Cisplatin (TP) + Radiation +/- Cetuximab in Larynx Carcinoma (CA)
Conditions: Squamous Cell Carcinoma of the Hypopharynx;   Larynx Carcinoma
Interventions: Radiation: Radiation;   Drug: Cetuximab;   Drug: Docetaxel;   Drug: Cisplatin (TP);   Drug: 5-Fluorouracil (TPF) (only until Feb 2009)
23 Recruiting Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Carboplatin Followed By Chemoradiation in Treating Patients With Recurrent Head and Neck Cancer
Conditions: Recurrent Salivary Gland Cancer;   Recurrent Squamous Cell Carcinoma of the Hypopharynx;   Recurrent Squamous Cell Carcinoma of the Larynx;   Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity;   Recurrent Squamous Cell Carcinoma of the Nasopharynx;   Recurrent Squamous Cell Carcinoma of the Oropharynx;   Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity;   Recurrent Verrucous Carcinoma of the Larynx;   Recurrent Verrucous Carcinoma of the Oral Cavity;   Salivary Gland Squamous Cell Carcinoma;   Tongue Cancer
Interventions: Drug: carboplatin;   Drug: paclitaxel albumin-stabilized nanoparticle formulation;   Drug: fluorouracil;   Drug: hydroxyurea;   Procedure: therapeutic conventional surgery;   Radiation: radiation therapy;   Radiation: hyperfractionated radiation therapy;   Other: laboratory biomarker analysis
24 Recruiting Intensity-Modulated Radiation Therapy, Pemetrexed Disodium, and Erlotinib Hydrochloride in Treating Patients With Recurrent or Second Primary Head and Neck Cancer
Conditions: Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma;   Recurrent Metastatic Squamous Neck Cancer With Occult Primary;   Recurrent Squamous Cell Carcinoma of the Hypopharynx;   Recurrent Squamous Cell Carcinoma of the Larynx;   Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity;   Recurrent Squamous Cell Carcinoma of the Oropharynx;   Recurrent Verrucous Carcinoma of the Larynx;   Recurrent Verrucous Carcinoma of the Oral Cavity
Interventions: Radiation: intensity-modulated radiation therapy;   Procedure: quality-of-life assessment;   Drug: erlotinib hydrochloride;   Drug: pemetrexed disodium;   Other: laboratory biomarker analysis;   Other: liquid chromatography;   Other: mass spectrometry;   Other: immunohistochemistry staining method;   Genetic: protein expression analysis
25 Not yet recruiting Phase I/II Study on Accelerated, Hyperfractionated Radiotherapy With Concomitant Cisplatin and Nimorazole
Condition: P16 Negative SCC Head and Neck Cancer of the Larynx, Pharynx and Oral Cavity
Intervention: Radiation: 76 Gy/ 56 fx/ 10/W with cisplatin 40 mg/m2/W and nimorazole
26 Not yet recruiting Induction Docetaxel/Cisplatin/5-fluorouracil (TPF) as Selector for Chemo Radiation Therapy (RT) Versus Partial Laryngectomy in Advanced Laryngeal Cancer
Condition: Larynx Cancer
Interventions: Procedure: laryngoscopy;   Drug: Taxotere (Docetaxel), Cisplatin, 5FU
27 Recruiting Adaptive, Image-guided, Intensity-modulated Radiotherapy for Head and Neck Cancer in the Reduced Volumes of Elective Neck
Conditions: Primary Non-operated Squamous Cell Carcinoma of Oral Cavity;   Primary Non-operated Squamous Cell Carcinoma of Oropharynx;   Primary Non-operated Squamous Cell Carcinoma of Hypopharynx;   Primary Non-operated Squamous Cell Carcinoma of Larynx
Interventions: Procedure: video fluoroscopy;   Procedure: extra imaging;   Other: scoring acute toxicity;   Other: scoring of late toxicity;   Other: scoring quality of life (QOL)
28 Recruiting The Objective is to Respond to Patients' Needs in the Field of Larynx Replacement
Conditions: Swallowing Disorders;   Dysphagia;   Laryngeal Neoplasms
Intervention: Device: Implantation of intralaryngeal prosthesis with a new double valve system, allowing tracheotomy closing
29 Unknown † Erlotinib, Celecoxib and Reirradiation for Recurrent Head and Neck Cancer
Conditions: Cancer of the Pharynx;   Cancer of the Larynx;   Cancer of the Neck;   Paranasal Sinus Neoplasms;   Cancer of the Head
Intervention: Drug: erlotinib + celecoxib
30 Not yet recruiting Speech and Swallowing Characteristics of Patients After Laryngectomy and the Effect on Quality of Life
Condition: Cancer of the Larynx
Intervention:
31 Recruiting Phase II Trial Evaluating Elimination of Radiation Therapy
Condition: Cancer of the Larynx
Intervention: Radiation: IMRT
32 Recruiting Nicotine Levels With Response Rates to Radiation Alone or With Chemo In Head & Neck Cancer
Conditions: Larynx Cancer;   Lip Cancer;   Oral Cavity Cancer;   Pharyngeal Cancer;   Oropharyngeal Cancer
Intervention:
33 Recruiting TPF Plus Radiotherapy and Cetuximab to Avoid Total Laryngectomy in Patients With Larynx Cancer
Condition: Head and Neck Cancer
Interventions: Drug: TPF, radiotherapy and cetuximab;   Procedure: H&N surgery
34 Recruiting Radiation With Cetuximab in Head and Neck Squamous Cell Carcinoma Who Do Not Qualify For Chemotherapy
Conditions: Squamous Cell Carcinoma of the Larynx, Hypopharynx, Oropharynx, or Oral Cavity.;   The Patients Will be Limited to Age 70 and Older,;   OR w/ Co-morbidities Precluding Treatment With Chemotherapy
Interventions: Procedure: Biopsy;   Procedure: 2 oral mucosa samples will be taken a week apart
35 Recruiting A Feasibility Study on Adaptive 18F-FDG-guided Radiotherapy for Recurrent and Second Primary Head and Neck Cancer in the Previously Irradiated Territory.
Conditions: Recurrent and Second Primary Squamous Cell Carcinoma of the Oral Cavity in the Previously Irradiated Territory in Case of Primary Unresectable Tumor.;   Recurrent and Second Primary Squamous Cell Carcinoma of the Oropharynx in the Previously Irradiated Territory in Case of Primary Unresectable Tumor.;   Recurrent and Second Primary Squamous Cell Carcinoma of the Hypopharynx in the Previously Irradiated Territory in Case of Primary Unresectable Tumor.;   Recurrent and Second Primary Squamous Cell Carcinoma of the Larynx in the Previously Irradiated Territory in Case of Primary Unresectable Tumor.
Intervention: Radiation: [18F]FDG-PET-voxel intensity-based IMRT
36 Recruiting Establishment of an Artificial Larynx After Total Laryngectomy
Condition: Carcinomatous Disease
Intervention: Device: PROTIP MEDICAL ( Artificial larynx prosthesis)
37 Recruiting Effect of Vaccination in Patients With Recurrent Respiratory Papillomatosis
Condition: Squamous Papilloma of the Larynx
Intervention: Biological: Silgard
38 Unknown † Intralesional Bevacizumab for Treating AIDS-associated Kaposi´s Sarcoma of the Larynx, Pharynx and Oral Cavity
Condition: Kaposi´s Sarcoma
Intervention: Drug: Bevacizumab
39 Recruiting A Study Comparing Adaptive Biological Imaging - Voxel Intensity - Based Radiotherapy (Adaptive Dose Escalation) Versus Standard Radiotherapy for Head and Neck Cancer
Condition: Primary Non-operated Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, Hypopharynx and Larynx.
Interventions: Radiation: Adaptive dose-painting-by-numbers;   Radiation: standard intensity-modulated radiotherapy (IMRT)
40 Unknown † Study of Blood and Tissue Samples From Patients With Larynx Cancer, Pharynx Cancer, or Oral Cavity Cancer
Condition: Head and Neck Cancer
Intervention: Other: laboratory biomarker analysis
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† Indicates status has not been verified in more than two years