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46601 studies found for:    "Molecular Mechanisms of Pharmacological Action"
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Rank Status Study
1 Completed Study in Infants With Infantile Hemangioma to Compare Propranolol Gel to Placebo
Condition: Infantile Hemangioma
Interventions: Drug: propranolol gel;   Drug: Placebo
2 Completed Caffeine for Motor Manifestations of Parkinson's Disease
Condition: Parkinson's Disease
Intervention: Drug: Caffeine alkaloid
3 Completed Open-label, Single-arm Study to Assess the Pharmacokinetics, Safety, and Tolerability of a Single Subcutaneous Dose of Icatibant in Healthy Japanese Volunteers
Condition: Hereditary Angioedema (HAE)
Intervention: Drug: Icatibant (30 mg)
4 Terminated
Has Results
SGN-30 and Combination Chemotherapy in Treating Patients With Newly Diagnosed Anaplastic Large Cell Lymphoma
Condition: Anaplastic Large Cell Lymphoma
Interventions: Drug: Cyclophosphamide;   Drug: Doxorubicin hydrochloride;   Drug: vincristine sulfate;   Drug: prednisone;   Drug: SGN-30
5 Active, not recruiting An Open Label Study of Postmenopausal Women With Oestrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer Treated With Everolimus (RAD001) With Exemestane, With Exploratory Epigenetic Marker Analysis
Condition: Oestrogen Receptor Positive Advanced Breast Cancer
Interventions: Drug: RAD001;   Drug: Exemestane
6 Completed
Has Results
Sofosbuvir (GS-7977) in Combination With PEG and Ribavirin for 12 Weeks in Treatment Experienced Subjects With Chronic HCV Infection Genotype 2 or 3
Condition: Hepatitis C
Interventions: Drug: SOF;   Drug: PEG;   Drug: RBV
7 Active, not recruiting A Phase 1b/2 Study in Asian Subjects With Non-Small Cell Lung Cancer
Conditions: Carcinoma, Non-Small Cell-Lung;   Lung Neoplasms;   Lung Cancer;   Respiratory Tract Neoplasms
Interventions: Biological: AV-299 + gefitinib;   Drug: Gefitinib
8 Recruiting Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of GS-9857 in Subjects With Chronic Hepatitis C Virus Infection
Condition: Hepatitis C Virus Infection
Interventions: Drug: GS-9857;   Drug: Placebo to match GS-9857
9 Unknown  Research Into the Effect of a Clot-dissolving Agent and Its Inhibitor
Condition: Acute Ischemic Stroke
Intervention:
10 Recruiting The Intravascular Cooling in the Treatment of Stroke 2/3 Trial
Condition: Stroke, Acute
Interventions: Device: hypothermia;   Other: Group1: IV t-PA and normothermia
11 Completed Pharmacokinetics, Safety and Tolerability of Escalating Rifapentine Doses in Healthy Volunteers
Conditions: Tuberculosis;   Tuberculosis, Pulmonary
Interventions: Drug: Rifampin & midazolam;   Drug: rifapentine & midazolam;   Drug: rifapentine and midazolam
12 Completed
Has Results
Safety and Efficacy of Ledipasvir/Sofosbuvir Fixed-Dose Combination ± Ribavirin in Treatment-Experienced Subjects With Genotype 1 HCV Infection
Condition: Chronic Hepatitis C Virus
Interventions: Drug: LDV/SOF;   Drug: RBV
13 Completed
Has Results
A Study to Assess the Safety, Tolerability and Glucose-Lowering Efficacy of MK-0893 in Participants With Type 2 Diabetes Mellitus (MK-0893-005)
Condition: Type 2 Diabetes Mellitus
Interventions: Drug: MK-0893;   Drug: Metformin;   Drug: Placebo
14 Recruiting Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse
Condition: Cocaine Dependence
Interventions: Drug: Doxazosin;   Drug: Placebo
15 Recruiting Tranexamic Acid in Reverse Total Shoulder Arthroplasty
Conditions: Shoulder Joint Disease;   Complications; Arthroplasty;   Intraoperative Complications;   Blood Loss, Surgical
Intervention: Drug: Infusion Tranexamic acid or placebo.
16 Completed A Study of MK-0893 on Glucagon-Induced Glycemic Excursion in Healthy Male Participants Following Intravenous Administration of Glucagon, Sandostatine® and Insulin (MK-0893-002)
Condition: Type 2 Diabetes Mellitus
Interventions: Drug: MK-0893 10 mg;   Drug: MK-0893 40 mg;   Drug: MK-0893 200 mg;   Drug: MK-0893 1000 mg;   Drug: Placebo;   Biological: Sandostatine®;   Biological: Insulin;   Biological: Glucagon
17 Completed Pregabalin for the Treatment of Pain After Posterior Spinal Fusions
Condition: Lumbar Spinal Fusions
Interventions: Drug: Pregabalin 150 mg;   Drug: Placebo
18 Completed Ezetimibe In Addition To Atorvastatin Therapy On The Plaque Composition In Patients With Acute Myocardial Infarction.
Condition: ST-Segment Elevation Myocardial Infarction
Interventions: Drug: Ezetimibe;   Drug: Placebo
19 Completed Phase I/II Study of KRN330 Plus Irinotecan in Patients With Metastatic Colorectal Cancer
Condition: Colorectal Cancer
Interventions: Biological: KRN330;   Drug: Irinotecan
20 Completed A Study of ET-743 (Trabectedin) in Patients With Advanced Breast Cancer
Conditions: Breast Neoplasms;   Neoplasms;   Neoplasms by Site;   Breast Diseases;   Skin Diseases
Intervention: Drug: ET743

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Indicates status has not been verified in more than two years