314 studies found for:    "Alkylating Agents" | updated in the last 30 days
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Rank Status Study
1 Recruiting Irinotecan, Temozolomide and Bevacizumab in Combination With Existing High Dose Alkylator Based Chemotherapy for Treatment of Newly Diagnosed Patients With Desmoplastic Small Round Cell Tumor
Conditions: Sarcoma;   Desmoplastic Small Round Cell Tumor (DSRCT)
Intervention: Drug: irinotecan, temozolomide, and bevacizumab incorporated into an existing schedule of high dose alkylator
2 Active, not recruiting Combination Of Lapatinib With Carboplatin, Paclitaxel and Trastuzumab In Metastatic Breast Cancer
Condition: Neoplasms, Breast
Interventions: Drug: lapatinib;   Drug: carboplatin;   Drug: trastuzumab;   Drug: paclitaxel
3 Recruiting Ph II Trial of Carboplatin and Pemetrexed With or Without AZD1775 for Untreated Lung Cancer
Condition: Previously Untreated Stage IV Non-Squamous Non Small Cell Lung Cancer
Interventions: Drug: AZD1775;   Drug: AZD1775 Matching Placebo;   Drug: pemetrexed;   Drug: carboplatin
4 Recruiting Low Dose Cyclophosphamide +/-- Nintedanib in Advanced Ovarian Cancer
Conditions: Ovarian Cancer;   Fallopian Tube Cancer
Intervention: Drug: BIBF 1120
5 Recruiting Neo Adjuvant Chemotherapy in Triple Negative Breast Cancer
Condition: Breast Cancer
Interventions: Drug: Carboplatin and Paclitaxel;   Drug: Doxorubicin, cyclophosphamide;   Drug: Doxorubicin, cyclophosphamide, carboplatin, thiotepa, cyclophosphamide
6 Recruiting Study of Intensive Chemotherapy, Surgery and Radiotherapy to Treat Ewing's Sarcoma in Children and Young Adults
Condition: Ewing's Sarcoma
Interventions: Drug: Chemotherapy;   Procedure: Surgery;   Radiation: Radiotherapy
7 Recruiting Bortezomib, Ifosfamide, Carboplatin, and Etoposide, With or Without Rituximab, in Treating Patients With Relapsed or Refractory AIDS-Related Non-Hodgkin Lymphoma
Condition: Lymphoma
Interventions: Biological: rituximab;   Drug: bortezomib;   Drug: carboplatin;   Drug: dexamethasone;   Drug: etoposide;   Drug: ifosfamide;   Genetic: polymerase chain reaction;   Genetic: western blotting
8 Active, not recruiting
Has Results
Cyclophosphamide, Rituximab, and Either Prednisone or Methylprednisolone in Treating Patients With Lymphoproliferative Disease After Solid Organ Transplantation
Condition: Lymphoproliferative Disorder
Interventions: Biological: rituximab;   Drug: cyclophosphamide;   Drug: methylprednisolone;   Drug: prednisone
9 Recruiting Standard Dose Bevacizumab Versus Low Dose Bevacizumab Plus Lomustine (CCNU) for Recurrent Glioblastoma Multiforme (GBM)
Conditions: Brain Cancer;   Glioblastoma
Interventions: Drug: Standard Dose Bevacizumab;   Drug: Low Dose  Bevacizumab;   Drug: Lomustine
10 Recruiting A Pilot Study of Immunotherapy Including Haploidentical NK Cell Infusion Following CD133+ Positively-Selected Autologous Hematopoietic Stem Cells in Children With High Risk Solid Tumors or Lymphomas
Conditions: Neuroblastoma;   Lymphoma;   High-risk Tumor
Interventions: Device: CD133+ selected autologous stem cell infusion;   Biological: IL-2;   Biological: hu14.18K322A;   Drug: Busulfan;   Drug: Melphalan;   Biological: GM-CSF;   Drug: Carmustine;   Drug: Etoposide;   Drug: Cytarabine;   Drug: Carboplatin;   Device: Haploidentical natural killer cell infusion;   Biological: G-CSF;   Drug: Etoposide phosphate
11 Recruiting Vorinostat Combined With Isotretinoin and Chemotherapy in Treating Younger Patients With Embryonal Tumors of the Central Nervous System
Conditions: Untreated Childhood Medulloblastoma;   Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor
Interventions: Drug: vorinostat;   Drug: isotretinoin;   Drug: vincristine sulfate;   Drug: cisplatin;   Drug: cyclophosphamide;   Drug: thiotepa;   Procedure: peripheral blood stem cell transplantation;   Radiation: 3-dimensional conformal radiation therapy;   Other: laboratory biomarker analysis
12 Recruiting Stem Cell Radiotherapy and Temozolomide for Newly Diagnosed High-grade Glioma
Conditions: Glioblastoma;   Malignant Glioma;   Brain Tumors;   Anaplastic Astrocytoma
Intervention: Radiation: Stem Cell Radiotherapy (ScRT) and Temozolomide
13 Active, not recruiting Vorinostat, Rituximab, and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Diffuse Large B-Cell Lymphoma
Conditions: Contiguous Stage II Adult Diffuse Large Cell Lymphoma;   Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma;   Stage III Adult Diffuse Large Cell Lymphoma;   Stage IV Adult Diffuse Large Cell Lymphoma
Interventions: Drug: vorinostat;   Biological: rituximab;   Drug: cyclophosphamide;   Drug: doxorubicin hydrochloride;   Drug: vincristine sulfate;   Drug: prednisone;   Other: laboratory biomarker analysis
14 Recruiting Chemoembolization With or Without Sorafenib Tosylate in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery
Conditions: Adult Primary Hepatocellular Carcinoma;   Localized Unresectable Adult Primary Liver Cancer;   Recurrent Adult Primary Liver Cancer
Interventions: Drug: sorafenib tosylate;   Other: placebo;   Drug: doxorubicin hydrochloride;   Drug: doxorubicin-eluting beads;   Drug: cisplatin;   Drug: mitomycin C;   Other: pharmacological study
15 Recruiting A Study of Trabectedin (YONDELIS) in Patients With Locally Advanced or Metastatic Liposarcoma or Leiomyosarcoma
Condition: Advanced or Metastatic Liposarcoma or Leiomyosarcoma
Interventions: Drug: Trabectedin;   Drug: Dacarbazine
16 Not yet recruiting GVAX Pancreas Vaccine (With CY) and CRS-207 With or Without Nivolumab
Condition: Previously Treated Metastatic Adenocarcinoma of the Pancreas
Interventions: Biological: CRS-207;   Biological: GVAX;   Drug: nivolumab;   Drug: CY
17 Recruiting A Study of GDC-0199 (ABT-199) Plus MabThera/Rituxan (Rituximab) Compared With Bendamustine Plus MabThera/Rituxan (Rituximab) in Patients With Relapsed or Resistant Chronic Lymphocytic Leukemia
Condition: Chronic Lymphocytic Leukemia
Interventions: Drug: Bendamustine;   Drug: GDC-0199;   Drug: Rituximab [MabThera/Rituxan]
18 Recruiting A Study of JNJ-54767414 (HuMax CD38) (Anti-CD38 Monoclonal Antibody) in Combination With Backbone Treatments for the Treatment of Patients With Multiple Myeloma
Condition: Multiple Myeloma
Interventions: Drug: Daratumumab;   Drug: Velcade;   Drug: Pomalidomide;   Drug: Dexamethasone;   Drug: Melphalan;   Drug: Prednisone;   Drug: Thalidomide;   Drug: Diphenhydramine;   Drug: Acetaminophen
19 Recruiting Ph 1b, Carfilzomib, Bendamustine, Dexamethasone in Multiple Myeloma
Condition: Myeloma
Interventions: Drug: Carfilzomib;   Drug: Bendamustine;   Drug: Dexamethasone
20 Completed
Has Results
Rituximab and Combination Chemotherapy in Treating Patients With Newly Diagnosed, HIV-Associated Burkitt's Lymphoma
Condition: Lymphoma
Interventions: Biological: filgrastim;   Biological: pegfilgrastim;   Biological: rituximab;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: doxorubicin hydrochloride;   Drug: etoposide;   Drug: ifosfamide;   Drug: leucovorin calcium;   Drug: liposomal cytarabine;   Drug: methotrexate;   Drug: therapeutic hydrocortisone;   Drug: vincristine sulfate

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