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76 studies found for:    sickle cell anemia OR sickle cell disease OR hemoglobin S disease OR hemoglobin SS disease | Open Studies | NIH, U.S. Fed

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Rank Status Study
1 Recruiting Blood Flow and Pain Crises in People With Sickle Cell Disease
Condition: Sickle Cell Disease
Intervention:
2 Recruiting Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia
Conditions: Pulmonary Hypertension;   Sickle Cell Anemia
Intervention:
3 Recruiting A Single Dose Study of the Safety, Blood Levels and Biological Effects of Aes-103 Compared to Placebo in Subjects With Stable Sickle Cell Disease
Condition: Anemia, Sickle Cell
Interventions: Drug: Aes-103;   Drug: Placebo
4 Recruiting Carbon Monoxide Levels and Sickle Cell Disease Severity
Conditions: Sickle Cell Disease;   Sickle Cell Anemia;   Anemia, Sickle Cell
Intervention:
5 Recruiting Topical Sodium Nitrite for Chronic Leg Ulcers in Adult Patients With Blood Disorders
Conditions: Sickle Cell Anemia;   Sickle Cell Disease;   Chronic Hemolytic Disorders
Intervention: Drug: Sodium Nitrite Cream
6 Recruiting Genetics and Pain Severity in Sickle Cell Disease
Conditions: Genotype;   Pain;   Sickle Cell Anemia;   Vaso-Occlusive Pain Crisis
Intervention:
7 Recruiting Microvessels and Heart Problems in Sickle Cell Disease
Condition: Sickle Cell Disease
Intervention:
8 Recruiting Blood Sampling for Research Related to Sickle Cell Disease
Conditions: Sickle Cell Trait;   Sickle Cell Disease
Intervention:
9 Recruiting Natural History of Sickle Cell Disease and Other Hemolytic Disorders
Conditions: Hemoglobin SC Disease;   Hematologic Diseases;   Sickle Cell Anemia;   Hemolytic Anemia
Intervention:
10 Recruiting Decitabine for High-Risk Sickle Cell Disease
Conditions: Neutropenia;   Sickle Cell Disease;   Decitabine;   Fetal Hemoglobin
Intervention: Drug: Decitabine
11 Recruiting Collection and Storage of Umbilical Cord Stem Cells for Treatment of Sickle Cell Disease
Conditions: Healthy;   Sickle Cell Anemia
Intervention:
12 Unknown † The Link Between Anemia and Deficits in Memory and Attention in Individuals With Sickle Cell Disease
Condition: Sickle Cell Disease
Intervention:
13 Unknown † Effectiveness of a Computerized Tool (PAINRelieveIt) to Help Manage Pain Related to Sickle Cell Disease
Conditions: Anemia, Sickle Cell;   Hemoglobin SC Disease
Interventions: Behavioral: PAINReportIt;   Behavioral: PAINUCope;   Behavioral: PAINConsultN
14 Recruiting Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Severe Congenital Anemias Including Sickle Cell Disease and Beta-Thalassemia
Conditions: Peripheral Blood Stem Cell Transplantation;   Anemia, Sickle Cell;   Graft-Versus-Host Disease;   Sirolimus (Rapamune(Registered Trademark));   Alemtuzumab (Campath(Registered Trademark))
Interventions: Procedure: PBMC Transplant;   Drug: Alemtuzumab (Campath(Registered Trademark));   Drug: Sirolimus (Rapamune(Registered Trademark));   Drug: Cyclophosphamide (Cytoxan(Registered Trademark));   Procedure: Low Dose Irradiation
15 Unknown † Phase I/II Randomized Study of Hydroxyurea With or Without Clotrimazole in Patients With Sickle Cell Anemia
Condition: Sickle Cell Anemia
Interventions: Drug: clotrimazole;   Drug: hydroxyurea
16 Unknown † Study of Clotrimazole and Hydroxyurea in Patients With Sickle Cell Syndromes
Condition: Sickle Cell Anemia
Interventions: Drug: clotrimazole;   Drug: hydroxyurea
17 Recruiting Nitric Oxide and Sickle Cell Pain
Conditions: Sickle Cell Disease;   Pain
Intervention:
18 Unknown † Arginine Treatment of Acute Chest Syndrome (Pneumonia) in Sickle Cell Disease Patients
Conditions: Anemia, Sickle Cell;   Pneumonia
Intervention: Drug: Arginine hydrochloride
19 Recruiting Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias
Conditions: Congenital Hemolytic Anemia;   Diamond-Blackfan Anemia
Interventions: Procedure: Radiotherapy;   Drug: Alemtuzumab (Campath(Registered Trademark));   Drug: Sirolimus (Rapamune(Registered Trademark))
20 Unknown † Phase II Randomized Trial of Arginine Butyrate Plus Standard Local Therapy in Patients With Refractory Sickle Cell Ulcers
Conditions: Skin Ulcers;   Sickle Cell Anemia
Intervention: Drug: arginine butyrate
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† Indicates status has not been verified in more than two years