52 studies found for:    "Multiple Sclerosis, Chronic Progressive"
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21 Recruiting ACTH in Progressive Forms of MS
Conditions: Secondary Progressive Multiple Sclerosis;   Primary Progressive Multiple Sclerosis;   Progressive Relapsing Multiple Sclerosis
Interventions: Drug: ACTH;   Drug: Placebo
22 Recruiting Safety, Tolerability and Activity Study of Ibudilast in Subjects With Progressive Multiple Sclerosis
Conditions: Multiple Sclerosis, Primary Progressive;   Multiple Sclerosis, Secondary Progressive
Interventions: Drug: ibudilast;   Drug: Placebo
23 Recruiting Exploring the Efficacy and Safety of Siponimod in Patients With Secondary Progressive Multiple Sclerosis (EXPAND)
Condition: Secondary Progressive Multiple Sclerosis
Interventions: Drug: BAF312;   Drug: Placebo
24 Completed Investigation of Simvastatin in Secondary Progressive Multiple Sclerosis
Condition: Secondary Progressive Multiple Sclerosis
Interventions: Drug: Simvastatin;   Drug: Placebo
25 Recruiting Double Blind Placebo-Controlled Phase I/II Clinical Trial of Idebenone in Patients With Primary Progressive Multiple Sclerosis (IPPoMS)
Condition: Primary Progressive Multiple Sclerosis
Intervention: Drug: Idebenone
26 Active, not recruiting Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS)
Condition: Multiple Sclerosis
Interventions: Other: Progressive exercise;   Device: Neuromuscular electrical stimulation delivered using the electrical therapy device EMPI 300 PV;   Other: Modified paleolithic diet;   Dietary Supplement: Omega 3 fatty acids;   Dietary Supplement: Full Spectrum vitamin;   Dietary Supplement: Essential - hydroxytyrosol;   Dietary Supplement: Maltodextrin fiber supplement;   Dietary Supplement: Mineral boost (magnesium);   Dietary Supplement: Niacinamide;   Dietary Supplement: Methyl B12;   Dietary Supplement: Taurine;   Dietary Supplement: creatine;   Dietary Supplement: thiamine;   Dietary Supplement: riboflavin;   Dietary Supplement: N acetylcysteine;   Dietary Supplement: alpha lipoic acid;   Dietary Supplement: L acetyl carnitine;   Dietary Supplement: methyl folate;   Dietary Supplement: coenzyme Q;   Behavioral: meditation;   Behavioral: self massage;   Behavioral: learning;   Dietary Supplement: Coconut oil
27 Completed A Randomised Controlled Trial of Neuroprotection With Lamotrigine in Secondary Progressive Multiple Sclerosis
Condition: Secondary Progressive Multiple Sclerosis
Intervention: Drug: Lamotrigine
28 Terminated A Study for Patients With Multiple Sclerosis
Condition: Secondary Progressive Multiple Sclerosis
Intervention: Drug: dirucotide
29 Completed Portuguese Observational Survey to Assess Drug Adherence in Patients With Multiple Sclerosis After Conversion to Betaferon by Using Elements of the BetaPlus Program - Nurse Support, Auto-injectors
Conditions: Relapsing Remitting Multiple Sclerosis (RRMS);   Secondary Progressive Multiple Sclerosis (SPMS)
Intervention: Drug: Interferon beta-1b (Betaseron, BAY86-5046)
30 Terminated Study Evaluating Mitoxantrone in Multiple Sclerosis
Condition: Secondary Progressive Multiple Sclerosis
Intervention: Drug: Mitoxantrone
31 Recruiting Idebenone for Primary Progressive Multiple Sclerosis
Conditions: Multiple Sclerosis;   Primary Progressive Multiple Sclerosis
Intervention: Drug: Idebenone
32 Not yet recruiting MS-SMART: Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial
Condition: Secondary Progressive Multiple Sclerosis
Interventions: Drug: Amiloride;   Drug: Riluzole;   Drug: Ibudilast;   Drug: Placebo
33 Recruiting Serial Collection of Primary Progressive Multiple Sclerosis Participants in the MURDOCK Study
Condition: Primary Progressive Multiple Sclerosis
Intervention: Other: generation of 'omic markers of disease progression
34 Recruiting Study of Tcelna (Imilecleucel-T) in Secondary Progressive Multiple Sclerosis
Conditions: Autoimmune Diseases of the Nervous System;   Multiple Sclerosis;   Secondary Progressive Multiple Sclerosis;   Disease Progression;   Brain Atrophy
Interventions: Biological: Tcelna;   Biological: Placebo
35 Completed Natalizumab Treatment of Progressive Multiple Sclerosis
Conditions: Primary Progressive Multiple Sclerosis;   Secondary Progressive Multiple Sclerosis
Intervention: Drug: Natalizumab
36 Active, not recruiting Autologous Mesenchymal Stem Cell (MSC) Transplantation in MS
Conditions: Relapsing-Remitting Multiple Sclerosis;   Secondary Progressive Multiple Sclerosis;   Progressive Relapsing Multiple Sclerosis
Intervention: Biological: Autologous mesenchymal stem cell transplantation
37 Active, not recruiting A Study of Ocrelizumab in Patients With Primary Progressive Multiple Sclerosis
Condition: Multiple Sclerosis, Primary Progressive
Interventions: Drug: ocrelizumab;   Drug: Placebo;   Drug: methylprednisolone
38 Unknown  Autologous Mesenchymal Stem Cells From Adipose Tissue in Patients With Secondary Progressive Multiple Sclerosis
Conditions: Autoimmune Diseases;   Immune System Diseases;   Demyelinating Diseases;   Nervous System Diseases;   Demyelinating Autoimmune Diseases, CNS;   Autoimmune Diseases of the Nervous System
Intervention: Other: Autologous mesenchymal stem cells from adipose tissue.
39 Recruiting A Pilot Study to Assess microRNA Biomarkers in Early and Later Stage Multiple Sclerosis
Conditions: Multiple Sclerosis;   Secondary Progressive Multiple Sclerosis;   Clinically Isolated Syndrome
Intervention:
40 Terminated Study to Compare Double-Dose Betaferon to the Approved Dose, for Patients With Early Secondary Progressive Multiple Sclerosis (SPMS)
Condition: Multiple Sclerosis
Intervention: Drug: Interferon beta-1b (Betaferon/Betaseron, BAY86-5046)

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Indicates status has not been verified in more than two years